Ly6/PLAUR domain-containing protein 1 (Putative HeLa tumor suppressor) (PHTS)
1_MWVLG 6_ IAATF 11_ CGLFL 16_ LPGFA 21_ LQIQC 26_ YQCEE 31_ FQLNN 36_ DCSSP 41_ EFIVN 46_ CTVNV 51_ QDMCQ 56_ KEVME 61_ QSAGI 66_ MYRKS 71_ CASSA 76_ ACLIA 81_ SAGYQ 86_ SFCSP 91_ GKLNS 96_ VCISC 101_ CNTPL 106_ CNGPR 111_ PKKRG 116_ SSASA 121_ LRPGL 126_ RTTIL 131_ FLKLA 136_LFSAH
1: Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro increases receptor desensitization and decreases affinity for ACh of alpha-4:beta-2-containing nAChRs. May play a role in the intracellular trafficking of alpha-4:beta-2 and alpha-7-containing nAChRs and may inhibit their expression at the cell surface. May be involved in the control of anxiety