E3 ubiquitin-protein ligase pellino homolog 3 (Pellino-3) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase pellino homolog 3)
1_MVLEG 6_ NPEVG 11_ SPRTS 16_ DLQHR 21_ GNKGS 26_ CVLSS 31_ PGEDA 36_ QPGEE 41_ PIKYG 46_ ELIVL 51_ GCCEE 56_ GGEET 61_ EAQRG 66_ EVTGP 71_ RAHSC 76_ YNGCL 81_ ASGDK 86_ GRRRS 91_ RLALS 96_ RRSHA 101_ NGVKP 106_ DVMHH 111_ ISTPL 116_ VSKAL 121_ SNRGQ 126_ HSISY 131_ TLSRS 136_ HSVIV 141_ EYTHD 146_ SDTDM 151_ FQIGR 156_ STENM 161_ IDFVV 166_ TDTSP 171_ GGGAA 176_ EGPSA 181_ QSTIS 186_ RYACR 191_ ILCDR 196_ RPPYT 201_ ARIYA 206_ AGFDA 211_ SSNIF 216_ LGERA 221_ AKWRT 226_ PDGLM 231_ DGLTT 236_ NGVLV 241_ MHPAG 246_ GFSED 251_ SAPGV 256_ WREIS 261_ VCGNV 266_ YTLRD 271_ SRSAQ 276_ QRGKL 281_ VENES 286_ NVLQD 291_ GSLID 296_ LCGAT 301_ LLWRT 306_ PAGLL 311_ RAPTL 316_ KQLEA 321_ QRQEA 326_ NAARP 331_ QCPVG 336_ LSTLA 341_ FPSPA 346_ RGRTA 351_ PDKQQ 356_ PWVYV 361_ RCGHV 366_ HGYHG 371_ WGCRR 376_ ERGPQ 381_ ERECP 386_ LCRLV 391_ GPYVP 396_ LWLGQ 401_ EAGLC 406_ LDPGP 411_ PSHAF 416_ APCGH 421_ VCSEK 426_ TARYW 431_ AQTPL 436_ PHGTH 441_ AFHAA 446_ CPFCG 451_ AWLTG 456_ EHGCV 461_RLIFQ
1: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:12874243, PubMed:17675297). Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6 (PubMed:12874243). Mediates 'Lys-63'-linked polyubiquitination of IRAK1 (PubMed:12874243). Can activate AP1/JUN and ELK1 (PubMed:12874243). Acts as a regulator of innate immunity by mediating 'Lys-63'-linked polyubiquitination of RIPK2 downstream of NOD1 and NOD2, thereby transforming RIPK2 into a scaffolding protein for downstream effectors, ultimately leading to activation of the NF-kappa-B and MAP kinases signaling (By similarity). Catalyzes 'Lys-63'-linked polyubiquitination of RIPK2 in parallel of XIAP (By similarity)