Lysophosphatidylserine lipase ABHD12 (EC 3.1.-.-) (2-arachidonoylglycerol hydrolase ABHD12) (Abhydrolase domain-containing protein 12) (hABHD12) (Monoacylglycerol lipase ABHD12) (EC 3.1.1.23) (Oxidized phosphatidylserine lipase ABHD12) (EC 3.1.-.-)
1_MRKRT 6_ EPVAL 11_ EHERC 16_ AAAGS 21_ SSSGS 26_ AAAAL 31_ DADCR 36_ LKQNL 41_ RLTGP 46_ AAAEP 51_ RCAAD 56_ AGMKR 61_ ALGRR 66_ KGVWL 71_ RLRKI 76_ LFCVL 81_ GLYIA 86_ IPFLI 91_ KLCPG 96_ IQAKL 101_ IFLNF 106_ VRVPY 111_ FIDLK 116_ KPQDQ 121_ GLNHT 126_ CNYYL 131_ QPEED 136_ VTIGV 141_ WHTVP 146_ AVWWK 151_ NAQGK 156_ DQMWY 161_ EDALA 166_ SSHPI 171_ ILYLH 176_ GNAGT 181_ RGGDH 186_ RVELY 191_ KVLSS 196_ LGYHV 201_ VTFDY 206_ RGWGD 211_ SVGTP 216_ SERGM 221_ TYDAL 226_ HVFDW 231_ IKARS 236_ GDNPV 241_ YIWGH 246_ SLGTG 251_ VATNL 256_ VRRLC 261_ ERETP 266_ PDALI 271_ LESPF 276_ TNIRE 281_ EAKSH 286_ PFSVI 291_ YRYFP 296_ GFDWF 301_ FLDPI 306_ TSSGI 311_ KFAND 316_ ENVKH 321_ ISCPL 326_ LILHA 331_ EDDPV 336_ VPFQL 341_ GRKLY 346_ SIAAP 351_ ARSFR 356_ DFKVQ 361_ FVPFH 366_ SDLGY 371_ RHKYI 376_ YKSPE 381_ LPRIL 386_ REFLG 391_KSEPE
1: Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes (PubMed:25290914, PubMed:30237167, PubMed:30420694, PubMed:30643283, PubMed:30720278). Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system (By similarity). Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal (PubMed:30643283). Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways (PubMed:22969151, PubMed:24027063). Has a strong preference for very-long-chain lipid substrates; substrate specificity is likely due to improved catalysis and not improved substrate binding (PubMed:30237167)