Glycerol-3-phosphate dehydrogenase 1-like protein (GPD1-L) (EC 1.1.1.8)
1_MAAAP 6_ LKVCI 11_ VGSGN 16_ WGSAV 21_ AKIIG 26_ NNVKK 31_ LQKFA 36_ STVKM 41_ WVFEE 46_ TVNGR 51_ KLTDI 56_ INNDH 61_ ENVKY 66_ LPGHK 71_ LPENV 76_ VAMSN 81_ LSEAV 86_ QDADL 91_ LVFVI 96_ PHQFI 101_ HRICD 106_ EITGR 111_ VPKKA 116_ LGITL 121_ IKGID 126_ EGPEG 131_ LKLIS 136_ DIIRE 141_ KMGID 146_ ISVLM 151_ GANIA 156_ NEVAA 161_ EKFCE 166_ TTIGS 171_ KVMEN 176_ GLLFK 181_ ELLQT 186_ PNFRI 191_ TVVDD 196_ ADTVE 201_ LCGAL 206_ KNIVA 211_ VGAGF 216_ CDGLR 221_ CGDNT 226_ KAAVI 231_ RLGLM 236_ EMIAF 241_ ARIFC 246_ KGQVS 251_ TATFL 256_ ESCGV 261_ ADLIT 266_ TCYGG 271_ RNRRV 276_ AEAFA 281_ RTGKT 286_ IEELE 291_ KEMLN 296_ GQKLQ 301_ GPQTS 306_ AEVYR 311_ ILKQK 316_ GLLDK 321_ FPLFT 326_ AVYQI 331_ CYESR 336_ PVQEM 341_ LSCLQ 346_SHPEH
1: Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L