Circadian-associated transcriptional repressor (ChIP-derived repressor of network oscillator) (Chrono) (Computationally highlighted repressor of the network oscillator)
1_MDSPS 6_ SVSSY 11_ SSYSL 16_ SSSFP 21_ TSPVN 26_ SDFGF 31_ PSDSE 36_ REDKG 41_ AHGPR 46_ PDTVG 51_ QRGGS 56_ RPSPG 61_ PIRCR 66_ HRSKV 71_ SGNQH 76_ TPSHP 81_ KQRGS 86_ ASPMA 91_ GSGAK 96_ RSRDG 101_ ELETS 106_ LNTQG 111_ CTTEG 116_ DLLFA 121_ QKCKE 126_ LQGFI 131_ PPLTD 136_ LLNGL 141_ KMGRF 146_ ERGLS 151_ SFQQS 156_ VAMDR 161_ IQRIV 166_ GVLQK 171_ PQMGE 176_ RYLGT 181_ LLQVE 186_ GMLKT 191_ WFPQI 196_ AAQKS 201_ SLGGG 206_ KHQLT 211_ KHFPS 216_ HHSDS 221_ AASSP 226_ ASPME 231_ KMDQT 236_ QLGHL 241_ ALKPK 246_ QPWHL 251_ TQWPA 256_ MNLTW 261_ IHTTP 266_ ICNPP 271_ LSSPG 276_ TISFS 281_ HGPLG 286_ TGTGI 291_ GVILF 296_ LQHGV 301_ QPFTH 306_ SAPTT 311_ PVPPT 316_ TASPV 321_ IPGEP 326_ MKLSG 331_ EGPRC 336_ YSLPV 341_ TLPSD 346_ WSYTL 351_ SPPSL 356_ PTLAR 361_ KMTIG 366_ HREQQ 371_ RSHPP 376_VAADA
1: Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Abrogates the interaction of BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK-BMAL1 heterodimer, reducing histone acetylation of its target genes. Rhythmically binds the E-box elements (5'-CACGTG-3') on circadian gene promoters and its occupancy shows circadian oscillation antiphasic to BMAL1. Interacts with the glucocorticoid receptor (NR3C1) and contributes to the repressive function in the glucocorticoid response (By similarity)