Leucine-rich repeat-containing protein 25 (Monocyte and plasmacytoid-activated protein)
1_MGGTL 6_ AWTLL 11_ LPLLL 16_ RESDS 21_ LEPSC 26_ TVSSA 31_ DVDWN 36_ AEFSA 41_ TCLNF 46_ SGLSL 51_ SLPHN 56_ QSLRA 61_ SNVIL 66_ LDLSG 71_ NGLRE 76_ LPVTF 81_ FAHLQ 86_ KLEVL 91_ NVLRN 96_ PLSRV 101_ DGALA 106_ ARCDL 111_ DLQAD 116_ CNCAL 121_ ESWHD 126_ IRRDN 131_ CSGQK 136_ PLLCW 141_ DTTSS 146_ QHNLS 151_ AFLEV 156_ SCAPG 161_ LASAT 166_ IGAVV 171_ VSGCL 176_ LLGLA 181_ IAGPV 186_ LAWRL 191_ WRCRV 196_ ARSRE 201_ LNKPW 206_ AAQDG 211_ PKPGL 216_ GLQPR 221_ YGSRS 226_ APKPQ 231_ VAVPS 236_ CPSTP 241_ DYENM 246_ FVGQP 251_ AAEHQ 256_ WDEQG 261_ AHPSE 266_ DNDFY 271_ INYKD 276_ IDLAS 281_ QPVYC 286_ NLQSL 291_ GQAPM 296_DEEEY
1: Plays a role in the inhibition of RLR-mediated type I interferon signaling pathway by targeting RIGI for autophagic degradation. Interacts specifically with ISG15-associated RIGI to promote interaction between RIGI and the autophagic cargo receptor p62/SQSTM1 to mediate RIGI degradation via selective autophagy (PubMed:29288164). Also plays a role in the inhibition of NF-kappa-B signaling pathway and inflammatory response by promoting the degradation of p65/RELA