Rho GTPase-activating protein 18 (MacGAP) (Rho-type GTPase-activating protein 18)
1_MSWLS 6_ SSQGV 11_ VLTAY 16_ HPSGK 21_ DQTVG 26_ NSHAK 31_ AGEEA 36_ TSSRR 41_ YGQYT 46_ MNQES 51_ TTIKV 56_ MEKPP 61_ FDRSI 66_ SQDSL 71_ DELSM 76_ EDYWI 81_ ELENI 86_ KKSSE 91_ NSQED 96_ QEVVV 101_ VKEPD 106_ EGELE 111_ EEWLK 116_ EAGLS 121_ NLFGE 126_ SAGDP 131_ QESIV 136_ FLSTL 141_ TRTQA 146_ AAVQK 151_ RVETV 156_ SQTLR 161_ KKNKQ 166_ YQIPD 171_ VRDIF 176_ AQQRE 181_ SKETA 186_ PGGTE 191_ SQSLR 196_ TNENK 201_ YQGRD 206_ DEASN 211_ LVGEE 216_ KLIPP 221_ EETPA 226_ PETDI 231_ NLEVS 236_ FAEQA 241_ LNQKE 246_ SSKEK 251_ IQKSK 256_ GDDAT 261_ LPSFR 266_ LPKDK 271_ TGTTR 276_ IGDLA 281_ PQDMK 286_ KVCHL 291_ ALIEL 296_ TALYD 301_ VLGIE 306_ LKQQK 311_ AVKIK 316_ TKDSG 321_ LFCVP 326_ LTALL 331_ EQDQR 336_ KVPGM 341_ RIPLI 346_ FQKLI 351_ SRIEE 356_ RGLET 361_ EGLLR 366_ IPGAA 371_ IRIKN 376_ LCQEL 381_ EAKFY 386_ EGTFN 391_ WESVK 396_ QHDAA 401_ SLLKL 406_ FIREL 411_ PQPLL 416_ SVEYL 421_ KAFQA 426_ VQNLP 431_ TKKQQ 436_ LQALN 441_ LLVIL 446_ LPDAN 451_ RDTLK 456_ ALLEF 461_ LQRVI 466_ DNKEK 471_ NKMTV 476_ MNVAM 481_ VMAPN 486_ LFMCH 491_ ALGLK 496_ SSEQR 501_ EFVMA 506_ AGTAN 511_ TMHLL 516_ IKYQK 521_ LLWTI 526_ PKFIV 531_ NQVRK 536_ QNTEN 541_ HKKDK 546_ RAMKK 551_ LLKKM 556_ AYDRE 561_ KYEKQ 566_ DKSTN 571_ DADVP 576_ QGVIR 581_ VQAPH 586_ LSKVS 591_ MAIQL 596_ TEELK 601_ ASDVL 606_ ARFLS 611_ QESGV 616_ AQTLK 621_ KGEVF 626_ LYEIG 631_ GNIGE 636_ RCLDD 641_ DTYMK 646_ DLYQL 651_ NPNAE 656_WVIKS
1: Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state (PubMed:21865595). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts downstream of YAP1 and inhibits actin polymerization, which in turn reduces nuclear localization of YAP1 (PubMed:25778702). Regulates cell shape, spreading, and migration (PubMed:21865595)