Activating signal cointegrator 1 complex subunit 3 (EC 3.6.4.12) (ASC-1 complex subunit p200) (ASC1p200) (Helicase, ATP binding 1) (Trip4 complex subunit p200)
1_MALPR 6_ LTGAL 11_ RSFSN 16_ VTKQD 21_ NYNEE 26_ VADLK 31_ IKRSK 36_ LHEQV 41_ LDLGL 46_ TWKKI 51_ IKFLN 56_ EKLEK 61_ SKMQS 66_ INEDL 71_ KDILH 76_ AAKQI 81_ VGTDN 86_ GREAI 91_ ESGAA 96_ FLFMT 101_ FHLKD 106_ SVGHK 111_ ETKAI 116_ KQMFG 121_ PFPSS 126_ SATAA 131_ CNATN 136_ RIISH 141_ FSQDD 146_ LTALV 151_ QMTEK 156_ EHGDR 161_ VFFGK 166_ NLAFS 171_ FDMHD 176_ LDHFD 181_ ELPIN 186_ GETQK 191_ TISLD 196_ YKKFL 201_ NEHLQ 206_ EACTP 211_ ELKPV 216_ EKTNG 221_ SFLWC 226_ EVEKY 231_ LNSTL 236_ KEMTE 241_ VPRVE 246_ DLCCT 251_ LYDML 256_ ASIKS 261_ GDELQ 266_ DELFE 271_ LLGPE 276_ GLELI 281_ EKLLQ 286_ NRITI 291_ VDRFL 296_ NSSND 301_ HRFQA 306_ LQDNC 311_ KKILG 316_ ENAKP 321_ NYGCQ 326_ VTIQS 331_ EQEKQ 336_ LMKQY 341_ RREEK 346_ RIARR 351_ EKKAG 356_ EDLEV 361_ SEGLM 366_ CFDPK 371_ ELRIQ 376_ REQAL 381_ LNARS 386_ VPILS 391_ RQRDA 396_ DVEKI 401_ HYPHV 406_ YDSQA 411_ EAMKT 416_ SAFIA 421_ GAKMI 426_ LPEGI 431_ QRENN 436_ KLYEE 441_ VRIPY 446_ SEPMP 451_ LSFEE 456_ KPVYI 461_ QDLDE 466_ IGQLA 471_ FKGMK 476_ RLNRI 481_ QSIVF 486_ ETAYN 491_ TNENM 496_ LICAP 501_ TGAGK 506_ TNIAM 511_ LTVLH 516_ EIRQH 521_ FQQGV 526_ IKKNE 531_ FKIVY 536_ VAPMK 541_ ALAAE 546_ MTDYF 551_ SRRLE 556_ PLGII 561_ VKELT 566_ GDMQL 571_ SKSEI 576_ LRTQM 581_ LVTTP 586_ EKWDV 591_ VTRKS 596_ VGDVA 601_ LSQIV 606_ RLLIL 611_ DEVHL 616_ LHEDR 621_ GPVLE 626_ SIVAR 631_ TLRQV 636_ ESTQS 641_ MIRIL 646_ GLSAT 651_ LPNYL 656_ DVATF 661_ LHVNP 666_ YIGLF 671_ FFDGR 676_ FRPVP 681_ LGQTF 686_ LGIKC 691_ ANKMQ 696_ QLNNM 701_ DEVCY 706_ ENVLK 711_ QVKAG 716_ HQVMV 721_ FVHAR 726_ NATVR 731_ TAMSL 736_ IERAK 741_ NCGHI 746_ PFFFP 751_ TQGHD 756_ YVLAE 761_ KQVQR 766_ SRNKQ 771_ VRELF 776_ PDGFS 781_ IHHAG 786_ MLRQD 791_ RNLVE 796_ NLFSN 801_ GHIKV 806_ LVCTA 811_ TLAWG 816_ VNLPA 821_ HAVII 826_ KGTQI 831_ YAAKR 836_ GSFVD 841_ LGILD 846_ VMQIF 851_ GRAGR 856_ PQFDK 861_ FGEGI 866_ IITTH 871_ DKLSH 876_ YLTLL 881_ TQRNP 886_ IESQF 891_ LESLA 896_ DNLNA 901_ EIALG 906_ TVTNV 911_ EEAVK 916_ WISYT 921_ YLYVR 926_ MRANP 931_ LAYGI 936_ SHKAY 941_ QIDPT 946_ LRKHR 951_ EQLVI 956_ EVGRK 961_ LDKAQ 966_ MIRFE 971_ ERTGY 976_ FSSTD 981_ LGRTA 986_ SHYYI 991_ KYNTI 996_ ETFNE 1001_ LFDAH 1006_ KTEGD 1011_ IFAIV 1016_ SKAEE 1021_ FDQIK 1026_ VREEE 1031_ IEELD 1036_ TLLSN 1041_ FCELS 1046_ TPGGV 1051_ ENSYG 1056_ KINIL 1061_ LQTYI 1066_ SRGEM 1071_ DSFSL 1076_ ISDSA 1081_ YVAQN 1086_ AARIV 1091_ RALFE 1096_ IALRK 1101_ RWPTM 1106_ TYRLL 1111_ NLSKV 1116_ IDKRL 1121_ WGWAS 1126_ PLRQF 1131_ SILPP 1136_ HILTR 1141_ LEEKK 1146_ LTVDK 1151_ LKDMR 1156_ KDEIG 1161_ HILHH 1166_ VNIGL 1171_ KVKQC 1176_ VHQIP 1181_ SVMME 1186_ ASIQP 1191_ ITRTV 1196_ LRVTL 1201_ SIYAD 1206_ FTWND 1211_ QVHGT 1216_ VGEPW 1221_ WIWVE 1226_ DPTND 1231_ HIYHS 1236_ EYFLA 1241_ LKKQV 1246_ ISKEA 1251_ QLLVF 1256_ TIPIF 1261_ EPLPS 1266_ QYYIR 1271_ AVSDR 1276_ WLGAE 1281_ AVCII 1286_ NFQHL 1291_ ILPER 1296_ HPPHT 1301_ ELLDL 1306_ QPLPI 1311_ TALGC 1316_ KAYEA 1321_ LYNFS 1326_ HFNPV 1331_ QTQIF 1336_ HTLYH 1341_ TDCNV 1346_ LLGAP 1351_ TGSGK 1356_ TVAAE 1361_ LAIFR 1366_ VFNKY 1371_ PTSKA 1376_ VYIAP 1381_ LKALV 1386_ RERMD 1391_ DWKVR 1396_ IEEKL 1401_ GKKVI 1406_ ELTGD 1411_ VTPDM 1416_ KSIAK 1421_ ADLIV 1426_ TTPEK 1431_ WDGVS 1436_ RSWQN 1441_ RNYVQ 1446_ QVTIL 1451_ IIDEI 1456_ HLLGE 1461_ ERGPV 1466_ LEVIV 1471_ SRTNF 1476_ ISSHT 1481_ EKPVR 1486_ IVGLS 1491_ TALAN 1496_ ARDLA 1501_ DWLNI 1506_ KQMGL 1511_ FNFRP 1516_ SVRPV 1521_ PLEVH 1526_ IQGFP 1531_ GQHYC 1536_ PRMAS 1541_ MNKPA 1546_ FQAIR 1551_ SHSPA 1556_ KPVLI 1561_ FVSSR 1566_ RQTRL 1571_ TALEL 1576_ IAFLA 1581_ TEEDP 1586_ KQWLN 1591_ MDERE 1596_ MENII 1601_ ATVRD 1606_ SNLKL 1611_ TLAFG 1616_ IGMHH 1621_ AGLHE 1626_ RDRKT 1631_ VEELF 1636_ VNCKV 1641_ QVLIA 1646_ TSTLA 1651_ WGVNF 1656_ PAHLV 1661_ IIKGT 1666_ EYYDG 1671_ KTRRY 1676_ VDFPI 1681_ TDVLQ 1686_ MMGRA 1691_ GRPQF 1696_ DDQGK 1701_ AVILV 1706_ HDIKK 1711_ DFYKK 1716_ FLYEP 1721_ FPVES 1726_ SLLGV 1731_ LSDHL 1736_ NAEIA 1741_ GGTIT 1746_ SKQDA 1751_ LDYIT 1756_ WTYFF 1761_ RRLIM 1766_ NPSYY 1771_ NLGDV 1776_ SHDSV 1781_ NKFLS 1786_ HLIEK 1791_ SLIEL 1796_ ELSYC 1801_ IEIGE 1806_ DNRSI 1811_ EPLTY 1816_ GRIAS 1821_ YYYLK 1826_ HQTVK 1831_ MFKDR 1836_ LKPEC 1841_ STEEL 1846_ LSILS 1851_ DAEEY 1856_ TDLPV 1861_ RHNED 1866_ HMNSE 1871_ LAKCL 1876_ PIESN 1881_ PHSFD 1886_ SPHTK 1891_ AHLLL 1896_ QAHLS 1901_ RAMLP 1906_ CPDYD 1911_ TDTKT 1916_ VLDQA 1921_ LRVCQ 1926_ AMLDV 1931_ AANQG 1936_ WLVTV 1941_ LNITN 1946_ LIQMV 1951_ IQGRW 1956_ LKDSS 1961_ LLTLP 1966_ NIENH 1971_ HLHLF 1976_ KKWKP 1981_ IMKGP 1986_ HARGR 1991_ TSIES 1996_ LPELI 2001_ HACGG 2006_ KDHVF 2011_ SSMVE 2016_ SELHA 2021_ AKTKQ 2026_ AWNFL 2031_ SHLPV 2036_ INVGI 2041_ SVKGS 2046_ WDDLV 2051_ EGHNE 2056_ LSVST 2061_ LTADK 2066_ RDDNK 2071_ WIKLH 2076_ ADQEY 2081_ VLQVS 2086_ LQRVH 2091_ FGFHK 2096_ GKPES 2101_ CAVTP 2106_ RFPKS 2111_ KDEGW 2116_ FLILG 2121_ EVDKR 2126_ ELIAL 2131_ KRVGY 2136_ IRNHH 2141_ VASLS 2146_ FYTPE 2151_ IPGRY 2156_ IYTLY 2161_ FMSDC 2166_ YLGLD 2171_ QQYDI 2176_ YLNVT 2181_ QASLS 2186_ AQVNT 2191_ KVSDS 2196_LTDLA
1: ATPase involved both in DNA repair and rescue of stalled ribosomes (PubMed:22055184, PubMed:28757607, PubMed:32099016, PubMed:32579943, PubMed:36302773). 3'-5' DNA helicase involved in repair of alkylated DNA: promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions (PubMed:22055184). Also involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation (PubMed:28757607, PubMed:32099016, PubMed:32579943, PubMed:36302773). Drives the splitting of stalled ribosomes that are ubiquitinated in a ZNF598-dependent manner, as part of the ribosome quality control trigger (RQT) complex (PubMed:28757607, PubMed:32099016, PubMed:32579943, PubMed:36302773). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347)