1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-3) (Phospholipase C-delta-3) (PLC-delta-3)
1_MLCGR 6_ WRRCR 11_ RPPEE 16_ PPVAA 21_ QVAAQ 26_ VAAPV 31_ ALPSP 36_ PTPSD 41_ GGTKR 46_ PGLRA 51_ LKKMG 56_ LTEDE 61_ DVRAM 66_ LRGSR 71_ LRKIR 76_ SRTWH 81_ KERLY 86_ RLQED 91_ GLSVW 96_ FQRRI 101_ PRAPS 106_ QHIFF 111_ VQHIE 116_ AVREG 121_ HQSEG 126_ LRRFG 131_ GAFAP 136_ ARCLT 141_ IAFKG 146_ RRKNL 151_ DLAAP 156_ TAEEA 161_ QRWVR 166_ GLTKL 171_ RARLD 176_ AMSQR 181_ ERLDH 186_ WIHSY 191_ LHRAD 196_ SNQDS 201_ KMSFK 206_ EIKSL 211_ LRMVN 216_ VDMND 221_ MYAYL 226_ LFKEC 231_ DHSNN 236_ DRLEG 241_ AEIEE 246_ FLRRL 251_ LKRPE 256_ LEEIF 261_ HQYSG 266_ EDRVL 271_ SAPEL 276_ LEFLE 281_ DQGEE 286_ GATLA 291_ RAQQL 296_ IQTYE 301_ LNETA 306_ KQHEL 311_ MTLDG 316_ FMMYL 321_ LSPEG 326_ AALDN 331_ THTCV 336_ FQDMN 341_ QPLAH 346_ YFISS 351_ SHNTY 356_ LTDSQ 361_ IGGPS 366_ STEAY 371_ VRAFA 376_ QGCRC 381_ VELDC 386_ WEGPG 391_ GEPVI 396_ YHGHT 401_ LTSKI 406_ LFRDV 411_ VQAVR 416_ DHAFT 421_ LSPYP 426_ VILSL 431_ ENHCG 436_ LEQQA 441_ AMARH 446_ LCTIL 451_ GDMLV 456_ TQALD 461_ SPNPE 466_ ELPSP 471_ EQLKG 476_ RVLVK 481_ GKKLP 486_ AARSE 491_ DGRAL 496_ SDREE 501_ EEEDD 506_ EEEEE 511_ EVEAA 516_ AQRRL 521_ AKQIS 526_ PELSA 531_ LAVYC 536_ HATRL 541_ RTLHP 546_ APNAP 551_ QPCQV 556_ SSLSE 561_ RKAKK 566_ LIREA 571_ GNSFV 576_ RHNAR 581_ QLTRV 586_ YPLGL 591_ RMNSA 596_ NYSPQ 601_ EMWNS 606_ GCQLV 611_ ALNFQ 616_ TPGYE 621_ MDLNA 626_ GRFLV 631_ NGQCG 636_ YVLKP 641_ ACLRQ 646_ PDSTF 651_ DPEYP 656_ GPPRT 661_ TLSIQ 666_ VLTAQ 671_ QLPKL 676_ NAEKP 681_ HSIVD 686_ PLVRI 691_ EIHGV 696_ PADCA 701_ RQETD 706_ YVLNN 711_ GFNPR 716_ WGQTL 721_ QFQLR 726_ APELA 731_ LVRFV 736_ VEDYD 741_ ATSPN 746_ DFVGQ 751_ FTLPL 756_ SSLKQ 761_ GYRHI 766_ HLLSK 771_ DGASL 776_ SPATL 781_FIQIR
1: Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow (PubMed:10336610). Regulates neurite outgrowth through the inhibition of RhoA/Rho kinase signaling (By similarity)