Cell adhesion molecule 2 (Immunoglobulin superfamily member 4D) (IgSF4D) (Nectin-like protein 3) (NECL-3) (Synaptic cell adhesion molecule 2) (SynCAM 2)
1_MIWKR 6_ SAVLR 11_ FYSVC 16_ GLLLQ 21_ GSQGQ 26_ FPLTQ 31_ NVTVV 36_ EGGTA 41_ ILTCR 46_ VDQND 51_ NTSLQ 56_ WSNPA 61_ QQTLY 66_ FDDKK 71_ ALRDN 76_ RIELV 81_ RASWH 86_ ELSIS 91_ VSDVS 96_ LSDEG 101_ QYTCS 106_ LFTMP 111_ VKTSK 116_ AYLTV 121_ LGVPE 126_ KPQIS 131_ GFSSP 136_ VMEGD 141_ LMQLT 146_ CKTSG 151_ SKPAA 156_ DIRWF 161_ KNDKE 166_ IKDVK 171_ YLKEE 176_ DANRK 181_ TFTVS 186_ STLDF 191_ RVDRS 196_ DDGVA 201_ VICRV 206_ DHESL 211_ NATPQ 216_ VAMQV 221_ LEIHY 226_ TPSVK 231_ IIPST 236_ PFPQE 241_ GQPLI 246_ LTCES 251_ KGKPL 256_ PEPVL 261_ WTKDG 266_ GELPD 271_ PDRMV 276_ VSGRE 281_ LNILF 286_ LNKTD 291_ NGTYR 296_ CEATN 301_ TIGQS 306_ SAEYV 311_ LIVHD 316_ VPNTL 321_ LPTTI 326_ IPSLT 331_ TATVT 336_ TTVAI 341_ TTSPT 346_ TSATT 351_ SSIRD 356_ PNALA 361_ GQNGP 366_ DHALI 371_ GGIVA 376_ VVVFV 381_ TLCSI 386_ FLLGR 391_ YLARH 396_ KGTYL 401_ TNEAK 406_ GAEDA 411_ PDADT 416_ AIINA 421_ EGSQV 426_NAEEK
1: Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes
2: (Microbial infection) Induces cell fusion in neuron infected by a neuropathogenic strain of measles. Interacts with measles hemagglutinin to trigger hyperfusogenic F-mediated membrane fusion and presumably transsynaptic cell-to-cell transmission of the virus