Protein PALS1 (MAGUK p55 subfamily member 5) (Membrane protein, palmitoylated 5) (Protein associated with Lin-7 1)
1_MTTSH 6_ MNGHV 11_ TEESD 16_ SEVKN 21_ VDLAS 26_ PEEHQ 31_ KHREM 36_ AVDCP 41_ GDLGT 46_ RMMPI 51_ RRSAQ 56_ LERIR 61_ QQQED 66_ MRRRR 71_ EEEGK 76_ KQELD 81_ LNSSM 86_ RLKKL 91_ AQIPP 96_ KTGID 101_ NPMFD 106_ TEEGI 111_ VLESP 116_ HYAVK 121_ ILEIE 126_ DLFSS 131_ LKHIQ 136_ HTLVD 141_ SQSQE 146_ DISLL 151_ LQLVQ 156_ NKDFQ 161_ NAFKI 166_ HNAIT 171_ VHMNK 176_ ASPPF 181_ PLISN 186_ AQDLA 191_ QEVQT 196_ VLKPV 201_ HHKEG 206_ QELTA 211_ LLNTP 216_ HIQAL 221_ LLAHD 226_ KVAEQ 231_ EMQLE 236_ PITDE 241_ RVYES 246_ IGQYG 251_ GETVK 256_ IVRIE 261_ KARDI 266_ PLGAT 271_ VRNEM 276_ DSVII 281_ SRIVK 286_ GGAAE 291_ KSGLL 296_ HEGDE 301_ VLEIN 306_ GIEIR 311_ GKDVN 316_ EVFDL 321_ LSDMH 326_ GTLTF 331_ VLIPS 336_ QQIKP 341_ PPAKE 346_ TVIHV 351_ KAHFD 356_ YDPSD 361_ DPYVP 366_ CRELG 371_ LSFQK 376_ GDILH 381_ VISQE 386_ DPNWW 391_ QAYRE 396_ GDEDN 401_ QPLAG 406_ LVPGK 411_ SFQQQ 416_ REAMK 421_ QTIEE 426_ DKEPE 431_ KSGKL 436_ WCAKK 441_ NKKKR 446_ KKVLY 451_ NANKN 456_ DDYDN 461_ EEILT 466_ YEEMS 471_ LYHQP 476_ ANRKR 481_ PIILI 486_ GPQNC 491_ GQNEL 496_ RQRLM 501_ NKEKD 506_ RFASA 511_ VPHTT 516_ RSRRD 521_ QEVAG 526_ RDYHF 531_ VSRQA 536_ FEADI 541_ AAGKF 546_ IEHGE 551_ FEKNL 556_ YGTSI 561_ DSVRQ 566_ VINSG 571_ KICLL 576_ SLRTQ 581_ SLKTL 586_ RNSDL 591_ KPYII 596_ FIAPP 601_ SQERL 606_ RALLA 611_ KEGKN 616_ PKPEE 621_ LREII 626_ EKTRE 631_ MEQNN 636_ GHYFD 641_ TAIVN 646_ SDLDK 651_ AYQEL 656_ LRLIN 661_ KLDTE 666_PQWVP
1: Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (PubMed:16678097, PubMed:25385611). Also involved in adherens junction biogenesis by ensuring correct localization of the exocyst complex protein EXOC4/SEC8 which allows trafficking of adherens junction structural component CDH1 to the cell surface (By similarity). Plays a role through its interaction with CDH5 in vascular lumen formation and endothelial membrane polarity (PubMed:27466317). Required during embryonic and postnatal retinal development (By similarity). Required for the maintenance of cerebellar progenitor cells in an undifferentiated proliferative state, preventing premature differentiation, and is required for cerebellar histogenesis, fissure formation, cerebellar layer organization and cortical development (By similarity). Plays a role in neuronal progenitor cell survival, potentially via promotion of mTOR signaling (By similarity). Plays a role in the radial and longitudinal extension of the myelin sheath in Schwann cells (By similarity). May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter (By similarity). Plays a role in the T-cell receptor-mediated activation of NF-kappa-B (PubMed:21479189). Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity). Required for the normal polarized localization of the vesicular marker STX4 (By similarity). Required for the correct trafficking of the myelin proteins PMP22 and MAG (By similarity). Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7 (By similarity)
2: (Microbial infection) Acts as an interaction partner for human coronaviruses SARS-CoV and, probably, SARS-CoV-2 envelope protein E which results in delayed formation of tight junctions and disregulation of cell polarity