F-box/WD repeat-containing protein 8 (F-box and WD-40 domain-containing protein 8) (F-box only protein 29)
1_MDDYS 6_ LDEFR 11_ RRWQE 16_ ELAQA 21_ QAPKK 26_ RRRPE 31_ AAERR 36_ ARRPE 41_ VGSGR 46_ GEQAS 51_ GDPAL 56_ AQRLL 61_ EGAGR 66_ PPAAR 71_ ATRAE 76_ GQDVA 81_ SRSRS 86_ PLARE 91_ GAGGG 96_ EQLVD 101_ QLIRD 106_ LNEMN 111_ DVPFF 116_ DIQLP 121_ YELAI 126_ NIFQY 131_ LDRKE 136_ LGRCA 141_ QVSKT 146_ WKVIA 151_ EDEVL 156_ WYRLC 161_ QQEGH 166_ LPDSS 171_ ISDYS 176_ CWKLI 181_ FQECR 186_ AKEHM 191_ LRTNW 196_ KNRKG 201_ AVSEL 206_ EHVPD 211_ TVLCD 216_ VHSHD 221_ GVVIA 226_ GYTSG 231_ DVRVW 236_ DTRTW 241_ DYVAP 246_ FLESE 251_ DEEDE 256_ PGMQP 261_ NVSFV 266_ RINSS 271_ LAVAA 276_ YEDGF 281_ LNIWD 286_ LRTGK 291_ YPVHR 296_ FEHDA 301_ RIQAL 306_ ALSQD 311_ DATVA 316_ TASAF 321_ DVVML 326_ SPNEE 331_ GYWQI 336_ AAEFE 341_ VPKLV 346_ QYLEI 351_ VPETR 356_ RYPVA 361_ VAAAG 366_ DLMYL 371_ LKAED 376_ SARTL 381_ LYAHG 386_ PPVTC 391_ LDVSA 396_ NQVAF 401_ GVQGL 406_ GWVYE 411_ GSKIL 416_ VYSLE 421_ AGRRL 426_ LKLGN 431_ VLRDF 436_ TCVNL 441_ SDSPP 446_ NLMVS 451_ GNMDG 456_ RVRIH 461_ DLRSG 466_ NIALS 471_ LSAHQ 476_ LRVSA 481_ VQMDD 486_ WKIVS 491_ GGEEG 496_ LVSVW 501_ DYRMN 506_ QKLWE 511_ VYSGH 516_ PVQHI 521_ SFSSH 526_ SLITA 531_ NVPYQ 536_ TVMRN 541_ ADLDS 546_ FTTHR 551_ RHRGL 556_ IRAYE 561_ FAVDQ 566_ LAFQS 571_ PLPVC 576_ RSSCD 581_ AMATH 586_ YYDLA 591_LAFPY
1: Substrate-recognition component of the Cul7-RING(FBXW8) ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:17205132, PubMed:18498745, PubMed:21572988, PubMed:24362026, PubMed:35982156). The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation (PubMed:24362026). The Cul7-RING(FBXW8) complex also mediates ubiquitination of phosphorylated cyclin-D1 (CCND1) (PubMed:17205132). The Cul7-RING(FBXW8) complex is however not a major regulator of CCND1 stability during the G1/S transition (By similarity). Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (PubMed:24793695)