Xylosyl- and glucuronyltransferase LARGE2 (EC 2.4.-.-) (Glycosyltransferase-like 1B) (LARGE xylosyl- and glucuronyltransferase 2) [Includes: Alpha-1,3-xylosyltransferase LARGE2 (EC 2.4.2.-); Beta-1,3-glucuronyltransferase LARGE2 (EC 2.4.1.-)]
1_MLPRG 6_ RPRAL 11_ GAAAL 16_ LLLLL 21_ LLGFL 26_ LFGGD 31_ LGCER 36_ REPGG 41_ RAGAP 46_ GCFPG 51_ PLMPR 56_ VPPDG 61_ RLRRA 66_ AALDG 71_ DPGAG 76_ PGDHN 81_ RSDCG 86_ PQPPP 91_ PPKCE 96_ LLHVA 101_ IVCAG 106_ HNSSR 111_ DVITL 116_ VKSML 121_ FYRKN 126_ PLHLH 131_ LVTDA 136_ VARNI 141_ LETLF 146_ HTWMV 151_ PAVRV 156_ SFYHA 161_ DQLKP 166_ QVSWI 171_ PNKHY 176_ SGLYG 181_ LMKLV 186_ LPSAL 191_ PAELA 196_ RVIVL 201_ DTDVT 206_ FASDI 211_ SELWA 216_ LFAHF 221_ SDTQA 226_ IGLVE 231_ NQSDW 236_ YLGNL 241_ WKNHR 246_ PWPAL 251_ GRGFN 256_ TGVIL 261_ LRLDR 266_ LRQAG 271_ WEQMW 276_ RLTAR 281_ RELLS 286_ LPATS 291_ LADQD 296_ IFNAV 301_ IKEHP 306_ GLVQR 311_ LPCVW 316_ NVQLS 321_ DHTLA 326_ ERCYS 331_ EASDL 336_ KVIHW 341_ NSPKK 346_ LRVKN 351_ KHVEF 356_ FRNFY 361_ LTFLE 366_ YDGNL 371_ LRREL 376_ FVCPS 381_ QPPPG 386_ AEQLQ 391_ QALAQ 396_ LDEED 401_ PCFEF 406_ RQQQL 411_ TVHRV 416_ HVTFL 421_ PHEPP 426_ PPRPH 431_ DVTLV 436_ AQLSM 441_ DRLQM 446_ LEALC 451_ RHWPG 456_ PMSLA 461_ LYLTD 466_ AEAQQ 471_ FLHFV 476_ EASPV 481_ LAARQ 486_ DVAYH 491_ VVYRE 496_ GPLYP 501_ VNQLR 506_ NVALA 511_ QALTP 516_ YVFLS 521_ DIDFL 526_ PAYSL 531_ YDYLR 536_ ASIEQ 541_ LGLGS 546_ RRKAA 551_ LVVPA 556_ FETLR 561_ YRFSF 566_ PHSKV 571_ ELLAL 576_ LDAGT 581_ LYTFR 586_ YHEWP 591_ RGHAP 596_ TDYAR 601_ WREAQ 606_ APYRV 611_ QWAAN 616_ YEPYV 621_ VVPRD 626_ CPRYD 631_ PRFVG 636_ FGWNK 641_ VAHIV 646_ ELDAQ 651_ EYELL 656_ VLPEA 661_ FTIHL 666_ PHAPS 671_ LDISR 676_ FRSSP 681_ TYRDC 686_ LQALK 691_ DEFHQ 696_ DLSRH 701_ HGAAA 706_ LKYLP 711_ ALQQP 716_QSPAR
1: Bifunctional glycosyltransferase with both alpha-1,3-xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the maturation of alpha-dystroglycan (DAG1) by glycosylation leading to DAG1 binding to laminin G-like domain-containing extracellular proteins with high affinity and in a phosphorylated-O-mannosyl trisaccharide dependent manner (PubMed:15661757, PubMed:15752776, PubMed:25138275). Elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide (By similarity). Supports the maturation of DAG1 more effectively than LARGE1 (PubMed:15752776). In addition, can modify both heparan sulfate (HS)- and chondroitin/dermatan sulfate (CS/DS)-proteoglycans (PGs), namely GPC4, with a glycosaminoglycan (GAG)-like polysaccharide composed of xylose and glucuronic acid to confer laminin binding (By similarity)