Leukocyte immunoglobulin-like receptor subfamily B member 2 (LIR-2) (Leukocyte immunoglobulin-like receptor 2) (CD85 antigen-like family member D) (Immunoglobulin-like transcript 4) (ILT-4) (Monocyte/macrophage immunoglobulin-like receptor 10) (MIR-10) (CD antigen CD85d)
1_MTPIV 6_ TVLIC 11_ LGLSL 16_ GPRTR 21_ VQTGT 26_ IPKPT 31_ LWAEP 36_ DSVIT 41_ QGSPV 46_ TLSCQ 51_ GSLEA 56_ QEYRL 61_ YREKK 66_ SASWI 71_ TRIRP 76_ ELVKN 81_ GQFHI 86_ PSITW 91_ EHTGR 96_ YGCQY 101_ YSRAR 106_ WSELS 111_ DPLVL 116_ VMTGA 121_ YPKPT 126_ LSAQP 131_ SPVVT 136_ SGGRV 141_ TLQCE 146_ SQVAF 151_ GGFIL 156_ CKEGE 161_ DEHPQ 166_ CLNSQ 171_ PHARG 176_ SSRAI 181_ FSVGP 186_ VSPNR 191_ RWSHR 196_ CYGYD 201_ LNSPY 206_ VWSSP 211_ SDLLE 216_ LLVPG 221_ VSKKP 226_ SLSVQ 231_ PGPVM 236_ APGES 241_ LTLQC 246_ VSDVG 251_ YDRFV 256_ LYKEG 261_ ERDLR 266_ QLPGR 271_ QPQAG 276_ LSQAN 281_ FTLGP 286_ VSRSY 291_ GGQYR 296_ CYGAH 301_ NLSSE 306_ CSAPS 311_ DPLDI 316_ LITGQ 321_ IRGTP 326_ FISVQ 331_ PGPTV 336_ ASGEN 341_ VTLLC 346_ QSWRQ 351_ FHTFL 356_ LTKAG 361_ AADAP 366_ LRLRS 371_ IHEYP 376_ KYQAE 381_ FPMSP 386_ VTSAH 391_ AGTYR 396_ CYGSL 401_ NSDPY 406_ LLSHP 411_ SEPLE 416_ LVVSG 421_ PSMGS 426_ SPPPT 431_ GPIST 436_ PGPED 441_ QPLTP 446_ TGSDP 451_ QSGLG 456_ RHLGV 461_ VIGIL 466_ VAVVL 471_ LLLLL 476_ LLLFL 481_ ILRHR 486_ RQGKH 491_ WTSTQ 496_ RKADF 501_ QHPAG 506_ AVGPE 511_ PTDRG 516_ LQWRS 521_ SPAAD 526_ AQEEN 531_ LYAAV 536_ KDTQP 541_ EDGVE 546_ MDTRA 551_ AASEA 556_ PQDVT 561_ YAQLH 566_ SLTLR 571_ RKATE 576_ PPPSQ 581_ EREPP 586_ AEPSI 591_YATLA
1: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles (PubMed:11169396, PubMed:12853576, PubMed:16455647, PubMed:20448110, PubMed:27859042). Involved in the down-regulation of the immune response and the development of tolerance. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance (PubMed:16455647, PubMed:20448110, PubMed:27859042). Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:11875462, PubMed:12853576, PubMed:9548455, PubMed:9842885)