Thioredoxin domain-containing protein 3 (NM23-H8) (NME/NM23 family member 8) (Spermatid-specific thioredoxin-2) (Sptrx-2)
1_MASKK 6_ REVQL 11_ QTVIN 16_ NQSLW 21_ DEMLQ 26_ NKGLT 31_ VIDVY 36_ QAWCG 41_ PCRAM 46_ QPLFR 51_ KLKNE 56_ LNEDE 61_ ILHFA 66_ VAEAD 71_ NIVTL 76_ QPFRD 81_ KCEPV 86_ FLFSV 91_ NGKII 96_ EKIQG 101_ ANAPL 106_ VNKKV 111_ INLID 116_ EERKI 121_ AAGEM 126_ ARPQY 131_ PEIPL 136_ VDSDS 141_ EVSEE 146_ SPCES 151_ VQELY 156_ SIAII 161_ KPDAV 166_ ISKKV 171_ LEIKR 176_ KITKA 181_ GFIIE 186_ AEHKT 191_ VLTEE 196_ QVVNF 201_ YSRIA 206_ DQCDF 211_ EEFVS 216_ FMTSG 221_ LSYIL 226_ VVSQG 231_ SKHNP 236_ PSEET 241_ EPQTD 246_ TEPNE 251_ RSEDQ 256_ PEVEA 261_ QVTPG 266_ MMKNK 271_ QDSLQ 276_ EYLER 281_ QHLAQ 286_ LCDIE 291_ EDAAN 296_ VAKFM 301_ DAFFP 306_ DFKKM 311_ KSMKL 316_ EKTLA 321_ LLRPN 326_ LFHER 331_ KDDVL 336_ RIIKD 341_ EDFKI 346_ LEQRQ 351_ VVLSE 356_ KEAQA 361_ LCKEY 366_ ENEDY 371_ FNKLI 376_ ENMTS 381_ GPSLA 386_ LVLLR 391_ DNGLQ 396_ YWKQL 401_ LGPRT 406_ VEEAI 411_ EYFPE 416_ SLCAQ 421_ FAMDS 426_ LPVNQ 431_ LYGSD 436_ SLETA 441_ EREIQ 446_ HFFPL 451_ QSTLG 456_ LIKPH 461_ ATSEQ 466_ REQIL 471_ KIVKE 476_ AGFDL 481_ TQVKK 486_ MFLTP 491_ EQIEK 496_ IYPKV 501_ TGKDF 506_ YKDLL 511_ EMLSV 516_ GPSMV 521_ MILTK 526_ WNAVA 531_ EWRRL 536_ MGPTD 541_ PEEAK 546_ LLSPD 551_ SIRAQ 556_ FGISK 561_ LKNIV 566_ HGASN 571_ AYEAK 576_ EVVNR 581_LFEDP
1: Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. In vitro, it has neither nucleoside diphosphate kinase (NDPK) activity nor reducing activity on disulfide bonds (PubMed:11737268). Exhibits a 3'-5' exonuclease activity with a preference for single-stranded DNA, suggesting roles in DNA proofreading and repair (PubMed:16313181)