D-2-hydroxyglutarate dehydrogenase, mitochondrial (EC 1.1.99.39)
1_MLPRR 6_ PLAWP 11_ AWLLR 16_ GAPGA 21_ AGSWG 26_ RPVGP 31_ LARRG 36_ CCSAP 41_ GTPEV 46_ PLTRE 51_ RYPVR 56_ RLPFS 61_ TVSKQ 66_ DLAAF 71_ ERIVP 76_ GGVVT 81_ DPEAL 86_ QAPNV 91_ DWLRT 96_ LRGCS 101_ KVLLR 106_ PRTSE 111_ EVSHI 116_ LRHCH 121_ ERNLA 126_ VNPQG 131_ GNTGM 136_ VGGSV 141_ PVFDE 146_ IILST 151_ ARMNR 156_ VLSFH 161_ SVSGI 166_ LVCQA 171_ GCVLE 176_ ELSRY 181_ VEERD 186_ FIMPL 191_ DLGAK 196_ GSCHI 201_ GGNVA 206_ TNAGG 211_ LRFLR 216_ YGSLH 221_ GTVLG 226_ LEVVL 231_ ADGTV 236_ LDCLT 241_ SLRKD 246_ NTGYD 251_ LKQLF 256_ IGSEG 261_ TLGII 266_ TTVSI 271_ LCPPK 276_ PRAVN 281_ VAFLG 286_ CPGFA 291_ EVLQT 296_ FSTCK 301_ GMLGE 306_ ILSAF 311_ EFMDA 316_ VCMQL 321_ VGRHL 326_ HLASP 331_ VQESP 336_ FYVLI 341_ ETSGS 346_ NAGHD 351_ AEKLG 356_ HFLEH 361_ ALGSG 366_ LVTDG 371_ TMATD 376_ QRKVK 381_ MLWAL 386_ RERIT 391_ EALSR 396_ DGYVY 401_ KYDLS 406_ LPVER 411_ LYDIV 416_ TDLRA 421_ RLGPH 426_ AKHVV 431_ GYGHL 436_ GDGNL 441_ HLNVT 446_ AEAFS 451_ PSLLA 456_ ALEPH 461_ VYEWT 466_ AGQQG 471_ SVSAE 476_ HGVGF 481_ RKRDV 486_ LGYSK 491_ PPGAL 496_ QLMQQ 501_ LKALL 506_ DPKGI 511_ LNPYK 516_TLPSQ
1: Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) to alpha-ketoglutarate (PubMed:15070399, PubMed:15609246, PubMed:16037974, PubMed:20020533, PubMed:33431826). Also catalyzes the oxidation of other D-2-hydroxyacids, such as D-malate (D-MAL) and D-lactate (D-LAC) (PubMed:33431826). Exhibits high activities towards D-2-HG and D-MAL but a very weak activity towards D-LAC (PubMed:33431826)