Secreted frizzled-related protein 1 (FRP-1) (sFRP-1) (Secreted apoptosis-related protein 2) (SARP-2)
1_MGIGR 6_ SEGGR 11_ RGAAL 16_ GVLLA 21_ LGAAL 26_ LAVGS 31_ ASEYD 36_ YVSFQ 41_ SDIGP 46_ YQSGR 51_ FYTKP 56_ PQCVD 61_ IPADL 66_ RLCHN 71_ VGYKK 76_ MVLPN 81_ LLEHE 86_ TMAEV 91_ KQQAS 96_ SWVPL 101_ LNKNC 106_ HAGTQ 111_ VFLCS 116_ LFAPV 121_ CLDRP 126_ IYPCR 131_ WLCEA 136_ VRDSC 141_ EPVMQ 146_ FFGFY 151_ WPEML 156_ KCDKF 161_ PEGDV 166_ CIAMT 171_ PPNAT 176_ EASKP 181_ QGTTV 186_ CPPCD 191_ NELKS 196_ EAIIE 201_ HLCAS 206_ EFALR 211_ MKIKE 216_ VKKEN 221_ GDKKI 226_ VPKKK 231_ KPLKL 236_ GPIKK 241_ KDLKK 246_ LVLYL 251_ KNGAD 256_ CPCHQ 261_ LDNLS 266_ HHFLI 271_ MGRKV 276_ KSQYL 281_ LTAIH 286_ KWDKK 291_ NKEFK 296_ NFMKK 301_ MKNHE 306_CPTFQ
1: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription