RING1 and YY1-binding protein (Apoptin-associating protein 1) (APAP-1) (Death effector domain-associated factor) (DED-associated factor) (YY1 and E4TF1-associated factor 1)
1_MTMGD 6_ KKSPT 11_ RPKRQ 16_ AKPAA 21_ DEGFW 26_ DCSVC 31_ TFRNS 36_ AEAFK 41_ CSICD 46_ VRKGT 51_ STRKP 56_ RINSQ 61_ LVAQQ 66_ VAQQY 71_ ATPPP 76_ PKKEK 81_ KEKVE 86_ KQDKE 91_ KPEKD 96_ KEISP 101_ SVTKK 106_ NTNKK 111_ TKPKS 116_ DILKD 121_ PPSEA 126_ NSIQS 131_ ANATT 136_ KTSET 141_ NHTSR 146_ PRLKN 151_ VDRST 156_ AQQLA 161_ VTVGN 166_ VTVII 171_ TDFKE 176_ KTRSS 181_ STSSS 186_ TVTSS 191_ AGSEQ 196_ QNQSS 201_ SGSES 206_ TDKGS 211_ SRSST 216_ PKGDM 221_SAVND
1: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132). Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females. May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites (By similarity). Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes (PubMed:19098711). May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis (PubMed:14765135, PubMed:27060496). May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1 (PubMed:11953439). May bind to DNA (By similarity). May play a role in the repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3 (PubMed:27748911)