Carnosine N-methyltransferase (EC 2.1.1.22)
1_MQRRR 6_ RPPPP 11_ TSRLP 16_ EGCGG 21_ GGGGS 26_ EEVEV 31_ QFSAG 36_ RWGSA 41_ AAVSA 46_ AAAAA 51_ TRSTE 56_ EEEER 61_ LEREH 66_ FWKII 71_ NAFRY 76_ YGTSM 81_ HERVN 86_ RTERQ 91_ FRSLP 96_ ANQQK 101_ LLPQF 106_ LLHLD 111_ KIRKC 116_ IDHNQ 121_ EILLT 126_ IVNDC 131_ IHMFE 136_ NKEYG 141_ EDGNG 146_ KIMPA 151_ STFDM 156_ DKLKS 161_ TLKQF 166_ VRDWS 171_ ETGKA 176_ ERDAC 181_ YQPII 186_ KEILK 191_ NFPKE 196_ RWDPS 201_ KVNIL 206_ VPGAG 211_ LGRLA 216_ WEIAM 221_ LGYAC 226_ QGNEW 231_ SFFML 236_ FSSNF 241_ VLNRC 246_ SEINK 251_ YKLYP 256_ WIHQF 261_ SNNRR 266_ SADQI 271_ RPIFF 276_ PDVDP 281_ HSLPP 286_ GSNFS 291_ MTAGD 296_ FQEIY 301_ SECNT 306_ WDCIA 311_ TCFFI 316_ DTAHN 321_ VIDYI 326_ DTIWK 331_ ILKPG 336_ GIWIN 341_ LGPLL 346_ YHFEN 351_ LANEL 356_ SIELS 361_ YEDIK 366_ NVVLQ 371_ YGFKV 376_ EVEKE 381_ SVLST 386_ YTVND 391_ LSMMK 396_ YYYEC 401_VLFVV
1: N-methyltransferase that catalyzes the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Anserine, a methylated derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of vertebrate skeletal muscles. Also methylates other L-histidine-containing di- and tripeptides such as Gly-Gly-His, Gly-His and homocarnosine (GABA-His)