Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (Type 2 PtdIns-4,5-P2 4-Ptase) (EC 3.1.3.78) (PtdIns-4,5-P2 4-Ptase II) (Transmembrane protein 55A)
1_MAADG 6_ VDERS 11_ PLLSA 16_ SHSGN 21_ VTPTA 26_ PPYLQ 31_ ESSPR 36_ AELPP 41_ PYTAI 46_ ASPDA 51_ SGIPV 56_ INCRV 61_ CQSLI 66_ NLDGK 71_ LHQHV 76_ VKCTV 81_ CNEAT 86_ PIKNP 91_ PTGKK 96_ YVRCP 101_ CNCLL 106_ ICKDT 111_ SRRIG 116_ CPRPN 121_ CRRII 126_ NLGPV 131_ MLISE 136_ EQPAQ 141_ PALPI 146_ QPEGT 151_ RVVCG 156_ HCGNT 161_ FLWME 166_ LRFNT 171_ LAKCP 176_ HCKKI 181_ SSVGS 186_ ALPRR 191_ RCCAY 196_ ITIGM 201_ ICIFI 206_ GVGLT 211_ VGTPD 216_ FARRF 221_ RATYV 226_ SWAIA 231_ YLLGL 236_ ICLIR 241_ ACYWG 246_ AIRVS 251_YPEHS
1: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (PubMed:16365287). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (PubMed:16365287). Negatively regulates the phagocytosis of large particles by reducing phagosomal phosphatidylinositol 4,5-bisphosphate accumulation during cup formation (By similarity)