Prostaglandin reductase 3 (PRG-3) (EC 1.3.1.48) (Zinc-binding alcohol dehydrogenase domain-containing protein 2)
1_MLRLV 6_ PTGAR 11_ AIVDM 16_ SYARH 21_ FLDFQ 26_ GSAIP 31_ QAMQK 36_ LVVTR 41_ LSPNF 46_ REAVT 51_ LSRDC 56_ PVPLP 61_ GDGDL 66_ LVRNR 71_ FVGVN 76_ ASDIN 81_ YSAGR 86_ YDPSV 91_ KPPFD 96_ IGFEG 101_ IGEVV 106_ ALGLS 111_ ASARY 116_ TVGQA 121_ VAYMA 126_ PGSFA 131_ EYTVV 136_ PASIA 141_ TPVPS 146_ VKPEY 151_ LTLLV 156_ SGTTA 161_ YISLK 166_ ELGGL 171_ SEGKK 176_ VLVTA 181_ AAGGT 186_ GQFAM 191_ QLSKK 196_ AKCHV 201_ IGTCS 206_ SDEKS 211_ AFLKS 216_ LGCDR 221_ PINYK 226_ TEPVG 231_ TVLKQ 236_ EYPEG 241_ VDVVY 246_ ESVGG 251_ AMFDL 256_ AVDAL 261_ ATKGR 266_ LIVIG 271_ FISGY 276_ QTPTG 281_ LSPVK 286_ AGTLP 291_ AKLLK 296_ KSASV 301_ QGFFL 306_ NHYLS 311_ KYQAA 316_ MSHLL 321_ EMCVS 326_ GDLVC 331_ EVDLG 336_ DLSPE 341_ GRFTG 346_ LESIF 351_ RAVNY 356_ MYMGK 361_ NTGKI 366_ VVELP 371_HSVNS
1: Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficiency towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation