3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) (3-ketoacyl-[acyl-carrier-protein] reductase beta subunit) (KAR beta subunit) (Carbonyl reductase family member 4) (CBR4) (Quinone reductase CBR4) (EC 1.6.5.10) (Short chain dehydrogenase/reductase family 45C member 1)
1_MDKVC 6_ AVFGG 11_ SRGIG 16_ RAVAQ 21_ LMARK 26_ GYRLA 31_ VIARN 36_ LEGAK 41_ AAAGD 46_ LGGDH 51_ LAFSC 56_ DVAKE 61_ HDVQN 66_ TFEEL 71_ EKHLG 76_ RVNFL 81_ VNAAG 86_ INRDG 91_ LLVRT 96_ KTEDM 101_ VSQLH 106_ TNLLG 111_ SMLTC 116_ KAAMR 121_ TMIQQ 126_ QGGSI 131_ VNVGS 136_ IVGLK 141_ GNSGQ 146_ SVYSA 151_ SKGGL 156_ VGFSR 161_ ALAKE 166_ VARKK 171_ IRVNV 176_ VAPGF 181_ VHTDM 186_ TKDLK 191_ EEHLK 196_ KNIPL 201_ GRFGE 206_ TIEVA 211_ HAVVF 216_ LLESP 221_ YITGH 226_ VLVVD 231_GGLQL
1: Component of the heterotetramer complex KAR (3-ketoacyl-[acyl carrier protein] reductase or 3-ketoacyl-[ACP] reductase) that forms part of the mitochondrial fatty acid synthase (mtFAS). Beta-subunit of the KAR heterotetramer complex, responsible for the 3-ketoacyl-ACP reductase activity of the mtFAS, reduces 3-oxoacyl-[ACP] to (3R)-hydroxyacyl-[ACP] in a NADPH-dependent manner with no chain length preference, thereby participating in mitochondrial fatty acid biosynthesis (PubMed:25203508). The homotetramer has NADPH-dependent quinone reductase activity (in vitro), hence could play a role in protection against cytotoxicity of exogenous quinones (PubMed:19000905). As a heterotetramer, it can also reduce 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro) (PubMed:19000905, PubMed:19571038, PubMed:25203508)