Gene name: TMEM199

Uniprot entry:

Q8N511

Protein names:

Transmembrane protein 199

Protein sequence:

1_MASSL 6_ LAGER 11_ LVRAL 16_ GPGGE 21_ LEPER 26_ LPRKL 31_ RAELE 36_ AALGK 41_ KHKGG 46_ DSSSG 51_ PQRLV 56_ SFRLI 61_ RDLHQ 66_ HLRER 71_ DSKLY 76_ LHELL 81_ EGSEI 86_ YLPEV 91_ VKPPR 96_ NPELV 101_ ARLEK 106_ IKIQL 111_ ANEEY 116_ KRITR 121_ NVTCQ 126_ DTRHG 131_ GTLSD 136_ LGKQV 141_ RSLKA 146_ LVITI 151_ FNFIV 156_ TVVAA 161_ FVCTY 166_ LGSQY 171_ IFTEM 176_ ASRVL 181_ AALIV 186_ ASVVG 191_ LAELY 196_ VMVRA 201_MEGEL

Protein annotations

Protein functions:

1: Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation (PubMed:28296633). May be involved in Golgi homeostasis (PubMed:26833330). Binds 20(S)-hydroxycholesterol (20(S)-OHC) (By similarity)