Melanoregulin (Dilute suppressor protein homolog)
1_MGLRD 6_ WLRTV 11_ CCCCG 16_ CECLE 21_ ERALP 26_ EKEPL 31_ VSDNN 36_ PYSSF 41_ GATLV 46_ RDDEK 51_ NLWSM 56_ PHDVS 61_ HTEAD 66_ DDRTL 71_ YNLIV 76_ IRNQQ 81_ AKDSE 86_ EWQKL 91_ NYDIH 96_ TLRQV 101_ RREVR 106_ NRWKC 111_ ILEDL 116_ GFQKE 121_ ADSLL 126_ SVTKL 131_ STISD 136_ SKNTR 141_ KAREM 146_ LLKLA 151_ EETNI 156_ FPTSW 161_ ELSER 166_ YLFVV 171_ DRLIA 176_ LDAAE 181_ EFFKL 186_ ARRTY 191_ PKKPG 196_ VPCLA 201_ DGQKE 206_LHYLP
1: Probably functions as a cargo-recognition protein that couples cytoplasmic vesicles to the transport machinery. Plays a role in hair pigmentation, a process that involves shedding of melanosome-containing vesicles from melanocytes, followed by phagocytosis of the melanosome-containing vesicles by keratinocytes. Functions on melanosomes as receptor for RILP and the complex formed by RILP and DCTN1, and thereby contributes to retrograde melanosome transport from the cell periphery to the center. Overexpression causes accumulation of late endosomes and/or lysosomes at the microtubule organising center (MTOC) at the center of the cell. Probably binds cholesterol and requires the presence of cholesterol in membranes to function in microtubule-mediated retrograde organelle transport. Binds phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate and phosphatidylinositol 3,5-bisphosphate, but not phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 4,5-bisphosphate (By similarity). Required for normal phagosome clearing and normal activation of lysosomal enzymes in lysosomes from retinal pigment epithelium cells (PubMed:19240024). Required for normal degradation of the lipofuscin component N-retinylidene-N-retinylethanolamine (A2E) in the eye. May function in membrane fusion and regulate the biogenesis of disk membranes of photoreceptor rod cells (By similarity)