MPN domain-containing protein (EC 3.4.-.-)
1_MAAPE 6_ PLSPA 11_ GGAGE 16_ EAPEE 21_ DEDEA 26_ EAEDP 31_ ERPNA 36_ GAGGG 41_ RSGGG 46_ GSSVS 51_ GGGGG 56_ GGAGA 61_ GGCGG 66_ PGGAL 71_ TRRAV 76_ TLRVL 81_ LKDAL 86_ LEPGA 91_ GVLSI 96_ YYLGK 101_ KFLGD 106_ LQPDG 111_ RIMWQ 116_ ETGQT 121_ FNSPS 126_ AWATH 131_ CKKLV 136_ NPAKK 141_ SGCGW 146_ ASVKY 151_ KGQKL 156_ DKYKA 161_ TWLRL 166_ HQLHT 171_ PATAA 176_ DESPA 181_ SEGEE 186_ EELLM 191_ EEEEE 196_ DVLAG 201_ VSAED 206_ KSRRP 211_ LGKSP 216_ SEPAH 221_ PEATT 226_ PGKRV 231_ DSKIR 236_ VPVRY 241_ CMLGS 246_ RDLAR 251_ NPHTL 256_ VEVTS 261_ FAAIN 266_ KFQPF 271_ NVAVS 276_ SNVLF 281_ LLDFH 286_ SHLTR 291_ SEVVG 296_ YLGGR 301_ WDVNS 306_ QMLTV 311_ LRAFP 316_ CRSRL 321_ GDAET 326_ AAAIE 331_ EEIYQ 336_ SLFLR 341_ GLSLV 346_ GWYHS 351_ HPHSP 356_ ALPSL 361_ QDIDA 366_ QMDYQ 371_ LRLQG 376_ SSNGF 381_ QPCLA 386_ LLCSP 391_ YYSGN 396_ PGPES 401_ KISPF 406_ WVMPP 411_ PEMLL 416_ VEFYK 421_ GSPDL 426_ VRLQE 431_ PWSQE 436_ HTYLD 441_ KLKIS 446_ LASRT 451_ PKDQS 456_ LCHVL 461_ EQVCG 466_VLKQG
1: Probable protease (By similarity). Acts as a sensor of N(6)-methyladenosine methylation on DNA (m6A): recognizes and binds m6A DNA, leading to its degradation (PubMed:30982744). Binds only double strand DNA (dsDNA) in a sequence-independent manner (By similarity)