Zinc finger CCCH-type with G patch domain-containing protein (G patch domain-containing protein 6) (Zinc finger CCCH domain-containing protein 9) (Zinc finger and G patch domain-containing protein)
1_MDEES 6_ LESAL 11_ QTYRA 16_ QLQQV 21_ ELALG 26_ AGLDS 31_ SEQAD 36_ LRQLQ 41_ GDLKE 46_ LIELT 51_ EASLV 56_ SVRKS 61_ SLLAA 66_ LDEER 71_ PGRQE 76_ DAEYQ 81_ AFREA 86_ ITEAV 91_ EAPAA 96_ ARGSG 101_ SETVP 106_ KAEAG 111_ PESAA 116_ GGQEE 121_ EEGED 126_ EEELS 131_ GTKVS 136_ APYYS 141_ SWGTL 146_ EYHNA 151_ MVVGT 156_ EEAED 161_ GSAGV 166_ RVLYL 171_ YPTHK 176_ SLKPC 181_ PFFLE 186_ GKCRF 191_ KENCR 196_ FSHGQ 201_ VVSLD 206_ ELRPF 211_ QDPDL 216_ SSLQA 221_ GSACL 226_ AKHQD 231_ GLWHA 236_ ARITD 241_ VDNGY 246_ YTVKF 251_ DSLLL 256_ REAVV 261_ EGDGI 266_ LPPLR 271_ TEATE 276_ SDSDS 281_ DGTGD 286_ SSYAR 291_ VVGSD 296_ AVDSA 301_ QSSAL 306_ CPSLA 311_ VVGSD 316_ AVDSG 321_ TCSSA 326_ FAGWE 331_ VHTRG 336_ IGSRL 341_ LTKMG 346_ YEFGK 351_ GLGRH 356_ AEGRV 361_ EPIHA 366_ VVLPR 371_ GKSLD 376_ QCVET 381_ LQKQT 386_ RVGKA 391_ GTNKP 396_ PRCRG 401_ RGARP 406_ GGRPA 411_ PRNVF 416_ DFLNE 421_ KLQGQ 426_ APGAL 431_ EAGAA 436_ PAGRR 441_ SKDMY 446_ HASKS 451_ AKRAL 456_ SLRLF 461_ QTEEK 466_ IERTQ 471_ RDIRS 476_ IQEAL 481_ ARNAG 486_ RHSVA 491_ SAQLQ 496_ EKLAG 501_ AQRQL 506_ GQLRA 511_ QEAGL 516_ QQEQR 521_ KADTH 526_KKMTE
1: Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis
2: Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex. Does not bind DNA