Ceramide synthase 5 (CerS5) (LAG1 longevity assurance homolog 5) (Sphingoid base N-palmitoyltransferase CERS5) (EC 2.3.1.291) (Sphingosine N-acyltransferase CERS5) (EC 2.3.1.24)
1_MATAA 6_ QGPLS 11_ LLWGW 16_ LWSER 21_ FWLPE 26_ NVSWA 31_ DLEGP 36_ ADGYG 41_ YPRGR 46_ HILSV 51_ FPLAA 56_ GIFFV 61_ RLLFE 66_ RFIAK 71_ PCALC 76_ IGIED 81_ SGPYQ 86_ AQPNA 91_ ILEKV 96_ FISIT 101_ KYPDK 106_ KRLEG 111_ LSKQL 116_ DWNVR 121_ KIQCW 126_ FRHRR 131_ NQDKP 136_ PTLTK 141_ FCESM 146_ WRFTF 151_ YLCIF 156_ CYGIR 161_ FLWSS 166_ PWFWD 171_ IRQCW 176_ HNYPF 181_ QPLSS 186_ GLYHY 191_ YIMEL 196_ AFYWS 201_ LMFSQ 206_ FTDIK 211_ RKDFL 216_ IMFVH 221_ HLVTI 226_ GLISF 231_ SYINN 236_ MVRVG 241_ TLIMC 246_ LHDVS 251_ DFLLE 256_ AAKLA 261_ NYAKY 266_ QRLCD 271_ TLFVI 276_ FSAVF 281_ MVTRL 286_ GIYPF 291_ WILNT 296_ TLFES 301_ WEIIG 306_ PYASW 311_ WLLNG 316_ LLLTL 321_ QLLHV 326_ IWSYL 331_ IARIA 336_ LKALI 341_ RGKVS 346_ KDDRS 351_ DVESS 356_ SEEED 361_ VTTCT 366_ KSPCD 371_ SSSSN 376_ GANRV 381_ NGHMG 386_GSYWA
1: Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA) (PubMed:16951403, PubMed:18541923, PubMed:22144673, PubMed:22661289, PubMed:23530041, PubMed:26887952, PubMed:29632068, PubMed:31916624). Can use other acyl donors, but with less efficiency (By similarity). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively (PubMed:31916624). Plays a role in de novo ceramide synthesis and surfactant homeostasis in pulmonary epithelia (By similarity)