TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 3) (NF-kappa-B-activating protein 1) (TAK1-binding protein 3) (TAB-3) (TGF-beta-activated kinase 1-binding protein 3)
1_MAQSS 6_ PQLDI 11_ QVLHD 16_ LRQRF 21_ PEIPE 26_ GVVSQ 31_ CMLQN 36_ NNNLE 41_ ACCRA 46_ LSQES 51_ SKYLY 56_ MEYHS 61_ PDDNR 66_ MNRNR 71_ LLHIN 76_ LGIHS 81_ PSSYH 86_ PGDGA 91_ QLNGG 96_ RTLVH 101_ SSSDG 106_ HIDPQ 111_ HAAGK 116_ QLICL 121_ VQEPH 126_ SAPAV 131_ VAATP 136_ NYNPF 141_ FMNEQ 146_ NRSAA 151_ TPPSQ 156_ PPQQP 161_ SSMQT 166_ GMNPS 171_ AMQGP 176_ SPPPP 181_ PPSYM 186_ HIPRY 191_ STNPI 196_ TVTVS 201_ QNLPS 206_ GQTVP 211_ RALQI 216_ LPQIP 221_ SNLYG 226_ SPGSI 231_ YIRQT 236_ SQSSS 241_ GRQTP 246_ QSTPW 251_ QSSPQ 256_ GPVPH 261_ YSQRP 266_ LPVYP 271_ HQQNY 276_ QPSQY 281_ SPKQQ 286_ QIPQS 291_ AYHSP 296_ PPSQC 301_ PSPFS 306_ SPQHQ 311_ VQPSQ 316_ LGHIF 321_ MPPSP 326_ STTPP 331_ HPYQQ 336_ GPPSY 341_ QKQGS 346_ HSVAY 351_ LPYTA 356_ SSLSK 361_ GSMKK 366_ IEITV 371_ EPSQR 376_ PGTAI 381_ NRSPS 386_ PISNQ 391_ PSPRN 396_ QHSLY 401_ TATTP 406_ PSSSP 411_ SRGIS 416_ SQPKP 421_ PFSVN 426_ PVYIT 431_ YTQPT 436_ GPSCT 441_ PSPSP 446_ RVIPN 451_ PTTVF 456_ KITVG 461_ RATTE 466_ NLLNL 471_ VDQEE 476_ RSAAP 481_ EPIQP 486_ ISVIP 491_ GSGGE 496_ KGSHK 501_ YQRSS 506_ SSGSD 511_ DYAYT 516_ QALLL 521_ HQRAR 526_ MERLA 531_ KQLKL 536_ EKEEL 541_ ERLKS 546_ EVNGM 551_ EHDLM 556_ QRRLR 561_ RVSCT 566_ TAIPT 571_ PEEMT 576_ RLRSM 581_ NRQLQ 586_ INVDC 591_ TLKEV 596_ DLLQS 601_ RGNFD 606_ PKAMN 611_ NFYDN 616_ IEPGP 621_ VVPPK 626_ PSKKD 631_ SSDPC 636_ TIERK 641_ ARRIS 646_ VTSKV 651_ QADIH 656_ DTQAA 661_ AADEH 666_ RTGST 671_ QSPRT 676_ QPRDE 681_ DYEGA 686_ PWNCD 691_ SCTFL 696_ NHPAL 701_ NRCEQ 706_CEMPR
1: Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122, PubMed:36593296). The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed:15327770, PubMed:18079694, PubMed:22158122)
2: May be an oncogenic factor