NF-kappa-B-activating protein
1_MAPVS 6_ GSRSP 11_ DREAS 16_ GSGGR 21_ RRSSS 26_ KSPKP 31_ SKSAR 36_ SPRGR 41_ RSRSH 46_ SCSRS 51_ GDRNG 56_ LTHQL 61_ GGLSQ 66_ GSRNQ 71_ SYRSR 76_ SRSRS 81_ RERPS 86_ APRGI 91_ PFASA 96_ SSSVY 101_ YGSYS 106_ RPYGS 111_ DKPWP 116_ SLLDK 121_ EREES 126_ LRQKR 131_ LSERE 136_ RIGEL 141_ GAPEV 146_ WGLSP 151_ KNPEP 156_ DSDEH 161_ TPVED 166_ EEPKK 171_ STTSA 176_ STSEE 181_ EKKKK 186_ SSRSK 191_ ERSKK 196_ RRKKK 201_ SSKRK 206_ HKKYS 211_ EDSDS 216_ DSDSE 221_ TDSSD 226_ EDNKR 231_ RAKKA 236_ KKKEK 241_ KKKHR 246_ SKKYK 251_ KKRSK 256_ KSRKE 261_ SSDSS 266_ SKESQ 271_ EEFLE 276_ NPWKD 281_ RTKAE 286_ EPSDL 291_ IGPEA 296_ PKTLT 301_ SQDDK 306_ PLNYG 311_ HALLP 316_ GEGAA 321_ MAEYV 326_ KAGKR 331_ IPRRG 336_ EIGLT 341_ SEEIA 346_ SFECS 351_ GYVMS 356_ GSRHR 361_ RMEAV 366_ RLRKE 371_ NQIYS 376_ ADEKR 381_ ALASF 386_ NQEER 391_ RKREN 396_ KILAS 401_ FREMV 406_YRKTK
1: Acts as a transcriptional repressor (PubMed:14550261, PubMed:19409814, PubMed:31587868). Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development (PubMed:19409814). Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter