Leucine repeat adapter protein 25
1_MNGLP 6_ SAEAP 11_ GGAGC 16_ ALAGL 21_ PPLPR 26_ GLSGL 31_ LNASG 36_ GSWRE 41_ LERVY 46_ SQRSR 51_ IHDEL 56_ SRAAR 61_ APDGP 66_ RHAAG 71_ AANAG 76_ PAAGP 81_ RRPVN 86_ LDSAL 91_ AALRK 96_ EMVGL 101_ RQLDM 106_ SLLCQ 111_ LWGLY 116_ ESIQD 121_ YKHLC 126_ QDLSF 131_ CQDLS 136_ SSLHS 141_ DSSYP 146_ PDAGL 151_ SDDEE 156_ PPDAS 161_ LPPDP 166_ PPLTV 171_ PQTHN 176_ ARDQW 181_LQDAF
1: Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation