SH2 domain-containing protein 3C (Cas/HEF1-associated signal transducer) (Chat-H) (Novel SH2-containing protein 3) (SH2 domain-containing Eph receptor-binding protein 1) (SHEP1)
1_MTEGT 6_ KKTSK 11_ KFKFF 16_ KFKGF 21_ GSLSN 26_ LPRSF 31_ TLRRS 36_ SASIS 41_ RQSHL 46_ EPDTF 51_ EATQD 56_ DMVTV 61_ PKSPP 66_ AYARS 71_ SDMYS 76_ HMGTM 81_ PRPSI 86_ KKAQN 91_ SQAAR 96_ QAQEA 101_ GPKPN 106_ LVPGG 111_ VPDPP 116_ GLEAA 121_ KEVMV 126_ KATGP 131_ LEDTP 136_ AMEPN 141_ PSAVE 146_ VDPIR 151_ KPEVP 156_ TGDVE 161_ EERPP 166_ RDVHS 171_ ERAAG 176_ EPEAG 181_ SDYVK 186_ FSKEK 191_ YILDS 196_ SPEKL 201_ HKELE 206_ EELKL 211_ SSTDL 216_ RSHAW 221_ YHGRI 226_ PREVS 231_ ETLVQ 236_ RNGDF 241_ LIRDS 246_ LTSLG 251_ DYVLT 256_ CRWRN 261_ QALHF 266_ KINKV 271_ VVKAG 276_ ESYTH 281_ IQYLF 286_ EQESF 291_ DHVPA 296_ LVRYH 301_ VGSRK 306_ AVSEQ 311_ SGAII 316_ YCPVN 321_ RTFPL 326_ RYLEA 331_ SYGLG 336_ QGSSK 341_ PASPV 346_ SPSGP 351_ KGSHM 356_ KRRSV 361_ TMTDG 366_ LTADK 371_ VTRSD 376_ GCPTS 381_ TSLPR 386_ PRDSI 391_ RSCAL 396_ SMDQI 401_ PDLHS 406_ PMSPI 411_ SESPS 416_ SPAYS 421_ TVTRV 426_ HAAPA 431_ APSAT 436_ ALPAS 441_ PVARR 446_ SSEPQ 451_ LCPGS 456_ APKTH 461_ GESDK 466_ GPHTS 471_ PSHTL 476_ GKASP 481_ SPSLS 486_ SYSDP 491_ DSGHY 496_ CQLQP 501_ PVRGS 506_ REWAA 511_ TETSS 516_ QQARS 521_ YGERL 526_ KELSE 531_ NGAPE 536_ GDWGK 541_ TFTVP 546_ IVEVT 551_ SSFNP 556_ ATFQS 561_ LLIPR 566_ DNRPL 571_ EVGLL 576_ RKVKE 581_ LLAEV 586_ DARTL 591_ ARHVT 596_ KVDCL 601_ VARIL 606_ GVTKE 611_ MQTLM 616_ GVRWG 621_ MELLT 626_ LPHGR 631_ QLRLD 636_ LLERF 641_ HTMSI 646_ MLAVD 651_ ILGCT 656_ GSAEE 661_ RAALL 666_ HKTIQ 671_ LAAEL 676_ RGTMG 681_ NMFSF 686_ AAVMG 691_ ALDMA 696_ QISRL 701_ EQTWV 706_ TLRQR 711_ HTEGA 716_ ILYEK 721_ KLKPF 726_ LKSLN 731_ EGKEG 736_ PPLSN 741_ TTFPH 746_ VLPLI 751_ TLLEC 756_ DSAPP 761_ EGPEP 766_ WGSTE 771_ HGVEV 776_ VLAHL 781_ EAART 786_ VAHHG 791_ GLYHT 796_ NAEVK 801_ LQGFQ 806_ ARPEL 811_ LEVFS 816_ TEFQM 821_ RLLWG 826_ SQGAS 831_ SSQAR 836_ RYEKF 841_ DKVLT 846_ ALSHK 851_LEPAV
1: Acts as an adapter protein that mediates cell signaling pathways involved in cellular functions such as cell adhesion and migration, tissue organization, and the regulation of the immune response (PubMed:12432078, PubMed:20881139). Plays a role in integrin-mediated cell adhesion through BCAR1-CRK-RAPGEF1 signaling and activation of the small GTPase RAP1 (PubMed:12432078). Promotes cell migration and invasion through the extracellular matrix (PubMed:20881139). Required for marginal zone B-cell development and thymus-independent type 2 immune responses (By similarity). Mediates migration and adhesion of B cells in the splenic marginal zone via promoting hyperphosphorylation of NEDD9/CASL (By similarity). Plays a role in CXCL13-induced chemotaxis of B-cells (By similarity). Plays a role in the migration of olfactory sensory neurons (OSNs) into the forebrain and the innervation of the olfactory bulb by the OSN axons during development (By similarity). Required for the efficient tyrosine phosphorylation of BCAR1 in OSN axons (By similarity)
2: Important regulator of chemokine-induced, integrin-mediated T lymphocyte adhesion and migration, acting upstream of RAP1 (By similarity). Required for tissue-specific adhesion of T lymphocytes to peripheral tissues (By similarity). Required for basal and CXCL2 stimulated serine-threonine phosphorylation of NEDD9 (By similarity). May be involved in the regulation of T-cell receptor-mediated IL2 production through the activation of the JNK pathway in T-cells (By similarity)
3: May be involved in the BCAR1/CAS-mediated JNK activation pathway