Arrestin domain-containing protein 1 (Alpha-arrestin 1)
1_MGRVQ 6_ LFEIS 11_ LSHGR 16_ VVYSP 21_ GEPLA 26_ GTVRV 31_ RLGAP 36_ LPFRA 41_ IRVTC 46_ IGSCG 51_ VSNKA 56_ NDTAW 61_ VVEEG 66_ YFNSS 71_ LSLAD 76_ KGSLP 81_ AGEHS 86_ FPFQF 91_ LLPAT 96_ APTSF 101_ EGPFG 106_ KIVHQ 111_ VRAAI 116_ HTPRF 121_ SKDHK 126_ CSLVF 131_ YILSP 136_ LNLNS 141_ IPDIE 146_ QPNVA 151_ SATKK 156_ FSYKL 161_ VKTGS 166_ VVLTA 171_ STDLR 176_ GYVVG 181_ QALQL 186_ HADVE 191_ NQSGK 196_ DTSPV 201_ VASLL 206_ QKVSY 211_ KAKRW 216_ IHDVR 221_ TIAEV 226_ EGAGV 231_ KAWRR 236_ AQWHE 241_ QILVP 246_ ALPQS 251_ ALPGC 256_ SLIHI 261_ DYYLQ 266_ VSLKA 271_ PEATV 276_ TLPVF 281_ IGNIA 286_ VNHAP 291_ VSPRP 296_ GLGLP 301_ PGAPP 306_ LVVPS 311_ APPQE 316_ EAEAE 321_ AAAGG 326_ PHFLD 331_ PVFLS 336_ TKSHS 341_ QRQPL 346_ LATLS 351_ SVPGA 356_ PEPCP 361_ QDGSP 366_ ASHPL 371_ HPPLC 376_ ISTGA 381_ TVPYF 386_ AEGSG 391_ GPVPT 396_ TSTLI 401_ LPPEY 406_ SSWGY 411_ PYEAP 416_ PSYEQ 421_ SCGGV 426_EPSLT
1: Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (PubMed:23886940, PubMed:27462458). Through an ubiquitination-dependent mechanism plays for instance a role in the incorporation of SLC11A2 into extracellular vesicles (PubMed:27462458). More generally, plays a role in the extracellular transport of proteins between cells through the release in the extracellular space of microvesicles (PubMed:22315426). By participating in the ITCH-mediated ubiquitination and subsequent degradation of NOTCH1, negatively regulates the NOTCH signaling pathway (PubMed:23886940)