Dehydrogenase/reductase SDR family member on chromosome X (EC 1.1.-.-) (DHRSXY) (Short chain dehydrogenase/reductase family 46C member 1) (Short chain dehydrogenase/reductase family 7C member 6)
1_MSPLS 6_ AARAA 11_ LRVYA 16_ VGAAV 21_ ILAQL 26_ LRRCR 31_ GGFLE 36_ PVFPP 41_ RPDRV 46_ AIVTG 51_ GTDGI 56_ GYSTA 61_ KHLAR 66_ LGMHV 71_ IIAGN 76_ NDSKA 81_ KQVVS 86_ KIKEE 91_ TLNDK 96_ VEFLY 101_ CDLAS 106_ MTSIR 111_ QFVQK 116_ FKMKK 121_ IPLHV 126_ LINNA 131_ GVMMV 136_ PQRKT 141_ RDGFE 146_ EHFGL 151_ NYLGH 156_ FLLTN 161_ LLLDT 166_ LKESG 171_ SPGHS 176_ ARVVT 181_ VSSAT 186_ HYVAE 191_ LNMDD 196_ LQSSA 201_ CYSPH 206_ AAYAQ 211_ SKLAL 216_ VLFTY 221_ HLQRL 226_ LAAEG 231_ SHVTA 236_ NVVDP 241_ GVVNT 246_ DVYKH 251_ VFWAT 256_ RLAKK 261_ LLGWL 266_ LFKTP 271_ DEGAW 276_ TSIYA 281_ AVTPE 286_ LEGVG 291_ GHYLY 296_ NEKET 301_ KSLHV 306_ TYNQK 311_ LQQQL 316_ WSKSC 321_EMTGV
1: Oxidoreductase that plays a key role in early steps of protein N-linked glycosylation by mediating two non-consecutive steps in dolichol biosynthesis (PubMed:38821050). Acts both as a NAD(+)-dependent dehydrogenase and as a NADPH-dependent reductase during the conversion of polyprenol into dolichol (PubMed:38821050). First catalyzes the NAD(+)-dependent dehydrogenation of polyprenol into polyprenal; polyprenal is then reduced into dolichal by SRD5A3 (PubMed:38821050). It then catalyzes the NADPH-dependent reduction of dolichal into dolichol (PubMed:38821050). May also acts as a positive regulator of starvation-induced autophagy (PubMed:25076851)