CDGSH iron-sulfur domain-containing protein 2 (Endoplasmic reticulum intermembrane small protein) (MitoNEET-related 1 protein) (Miner1) (Nutrient-deprivation autophagy factor-1) (NAF-1)
1_MVLES 6_ VARIV 11_ KVQLP 16_ AYLKR 21_ LPVPE 26_ SITGF 31_ ARLTV 36_ SEWLR 41_ LLPFL 46_ GVLAL 51_ LGYLA 56_ VRPFL 61_ PKKKQ 66_ QKDSL 71_ INLKI 76_ QKENP 81_ KVVNE 86_ INIED 91_ LCLTK 96_ AAYCR 101_ CWRSK 106_ TFPAC 111_ DGSHN 116_ KHNEL 121_ TGDNV 126_GPLIL
1: Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy