Protein jagunal homolog 1
1_MASRA 6_ GPRAA 11_ GTDGS 16_ DFQHR 21_ ERVAM 26_ HYQMS 31_ VTLKY 36_ EIKKL 41_ IYVHL 46_ VIWLL 51_ LVAKM 56_ SVGHL 61_ RLLSH 66_ DQVAM 71_ PYQWE 76_ YPYLL 81_ SILPS 86_ LLGLL 91_ SFPRN 96_ NISYL 101_ VLSMI 106_ SMGLF 111_ SIAPL 116_ IYGSM 121_ EMFPA 126_ AQQLY 131_ RHGKA 136_ YRFLF 141_ GFSAV 146_ SIMYL 151_ VLVLA 156_ VQVHA 161_ WQLYY 166_ SKKLL 171_ DSWFT 176_STQEK
1: Endoplasmic reticulum transmembrane protein involved in vesicle-mediated transport, which is required for neutrophil function. Required for vesicle-mediated transport; it is however unclear whether it is involved in early secretory pathway or intracellular protein transport. Acts as a regulator of neutrophil function, probably via its role in vesicle-mediated transport: required for defense against fungal pathogens and for granulocyte colony-stimulating factor (GM-CSF) signaling pathway; possibly by regulating glycosylation and/or targeting of proteins contributing to the viability and migration of neutrophils