Zinc finger CCCH domain-containing protein 8
1_MDFEN 6_ LFSKP 11_ PNPAL 16_ GKTAT 21_ DSDER 26_ IDDEI 31_ DTEVE 36_ ETQEE 41_ KIKLE 46_ CEQIP 51_ KKFRH 56_ SAISP 61_ KSSLH 66_ RKSRS 71_ KDYDV 76_ YSDND 81_ ICSQE 86_ SEDNF 91_ AKELQ 96_ QYIQA 101_ REMAN 106_ AAQPE 111_ ESTKK 116_ EGVKD 121_ TPQAA 126_ KQKNK 131_ NLKAG 136_ HKNGK 141_ QKKMK 146_ RKWPG 151_ PGNKG 156_ SNALL 161_ RNSGS 166_ QEEDG 171_ KPKEK 176_ QQHLS 181_ QAFIN 186_ QHTVE 191_ RKGKQ 196_ ICKYF 201_ LERKC 206_ IKGDQ 211_ CKFDH 216_ DAEIE 221_ KKKEM 226_ CKFYV 231_ QGYCT 236_ RGENC 241_ LYLHN 246_ EYPCK 251_ FYHTG 256_ TKCYQ 261_ GEYCK 266_ FSHAP 271_ LTPET 276_ QELLA 281_ KVLDT 286_EKKSC
1: Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity). Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:23932780). Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis