RING finger protein 10
1_MPLSS 6_ PNAAA 11_ TASDM 16_ DKNSG 21_ SNSSS 26_ ASSGS 31_ SKGQQ 36_ PPRSA 41_ SAGPA 46_ GESKP 51_ KSDGK 56_ NSSGS 61_ KRYNR 66_ KRELS 71_ YPKNE 76_ SFNNQ 81_ SRRSS 86_ SQKSK 91_ TFNKM 96_ PPQRG 101_ GGSSK 106_ LFSSS 111_ FNGGR 116_ RDEVA 121_ EAQRA 126_ EFSPA 131_ QFSGP 136_ KKINL 141_ NHLLN 146_ FTFEP 151_ RGQTG 156_ HFEGS 161_ GHGSW 166_ GKRNK 171_ WGHKP 176_ FNKEL 181_ FLQAN 186_ CQFVV 191_ SEDQD 196_ YTAHF 201_ ADPDT 206_ LVNWD 211_ FVEQV 216_ RICSH 221_ EVPSC 226_ PICLY 231_ PPTAA 236_ KITRC 241_ GHIFC 246_ WACIL 251_ HYLSL 256_ SEKTW 261_ SKCPI 266_ CYSSV 271_ HKKDL 276_ KSVVA 281_ TESHQ 286_ YVVGD 291_ TITMQ 296_ LMKRE 301_ KGVLV 306_ ALPKS 311_ KWMNV 316_ DHPIH 321_ LGDEQ 326_ HSQYS 331_ KLLLA 336_ SKEQV 341_ LHRVV 346_ LEEKV 351_ ALEQQ 356_ LAEEK 361_ HTPES 366_ CFIEA 371_ AIQEL 376_ KTREE 381_ ALSGL 386_ AGSRR 391_ EVTGV 396_ VAALE 401_ QLVLM 406_ APLAK 411_ ESVFQ 416_ PRKGV 421_ LEYLS 426_ AFDEE 431_ TTEVC 436_ SLDTP 441_ SRPLA 446_ LPLVE 451_ EEEAV 456_ SEPEP 461_ EGLPE 466_ ACDDL 471_ ELADD 476_ NLKEG 481_ TICTE 486_ SSQQE 491_ PITKS 496_ GFTRL 501_ SSSPC 506_ YYFYQ 511_ AEDGQ 516_ HMFLH 521_ PVNVR 526_ CLVRE 531_ YGSLE 536_ RSPEK 541_ ISATV 546_ VEIAG 551_ YSMSE 556_ DVRQR 561_ HRYLS 566_ HLPLT 571_ CEFSI 576_ CELAL 581_ QPPVV 586_ SKETL 591_ EMFSD 596_ DIEKR 601_ KRQRQ 606_ KKARE 611_ ERRRE 616_ RRIEI 621_ EENKK 626_ QGKYP 631_ EVHIP 636_ LENLQ 641_ QFPAF 646_ NSYTC 651_ SSDSA 656_ LGPTS 661_ TEGHG 666_ ALSIS 671_ PLSRS 676_ PGSHA 681_ DFLLT 686_ PLSPT 691_ ASQGS 696_ PSFCV 701_ GSLEE 706_ DSPFP 711_ SFAQM 716_ LRVGK 721_ AKADV 726_ WPKTA 731_ PKKDE 736_ NSLVP 741_ PAPVD 746_ SDGES 751_ DNSDR 756_ VPVPS 761_ FQNSF 766_ SQAIE 771_ AAFMK 776_ LDTPA 781_ TSDPL 786_ SEEKG 791_ GKKRK 796_ KQKQK 801_ LLFST 806_SVVHT
1: E3 ubiquitin-protein ligase that catalyzes monoubiquitination of 40S ribosomal proteins RPS2/us5 and RPS3/us3 in response to ribosome stalling (PubMed:34348161, PubMed:34469731). Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): RNF10 acts by mediating monoubiquitination of RPS2/us5 and RPS3/us3, promoting their degradation by the proteasome (PubMed:34348161, PubMed:34469731). Also promotes ubiquitination of 40S ribosomal proteins in response to ribosome stalling during translation elongation (PubMed:34348161). The action of RNF10 in iRQC is counteracted by USP10 (PubMed:34469731). May also act as a transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression (By similarity). Acts as a regulator of Schwann cell differentiation and myelination (By similarity)