Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor)
1_METRE 6_ SEDLE 11_ KTRRK 16_ SASDQ 21_ WNTDN 26_ EPAKV 31_ KPELL 36_ PEKEE 41_ TSQAD 46_ QDIQD 51_ KEPHC 56_ HIPIK 61_ RNSIF 66_ NRSIR 71_ RKSKA 76_ KARDN 81_ PERNA 86_ SCLAD 91_ SQDNG 96_ KSVNE 101_ PLTLN 106_ IPWSR 111_ MPPCR 116_ TAMQT 121_ DPGAQ 126_ EMSES 131_ SSTPG 136_ NGATP 141_ EEWPA 146_ LADSP 151_ TTLTE 156_ ALRMI 161_ HPIPA 166_ DSWRN 171_ LIEQI 176_ GLLYQ 181_ EYRDK 186_ STLQE 191_ IETRR 196_ QQDAE 201_ IEDNT 206_ NGSPA 211_ SEDTP 216_ EEEEE 221_ EEEEE 226_ EPASP 231_ PERKT 236_ LPQIC 241_ LLSNP 246_ HSRFN 251_ LWQDL 256_ PEIRS 261_ SGVLE 266_ ILQPE 271_ EIKLQ 276_ EAMFE 281_ LVTSE 286_ ASYYK 291_ SLNLL 296_ VSHFM 301_ ENERI 306_ RKILH 311_ PSEAH 316_ ILFSN 321_ VLDVL 326_ AVSER 331_ FLLEL 336_ EHRME 341_ ENIVI 346_ SDVCD 351_ IVYRY 356_ AADHF 361_ SVYIT 366_ YVSNQ 371_ TYQER 376_ TYKQL 381_ LQEKA 386_ AFREL 391_ IAQLE 396_ LDPKC 401_ RGLPF 406_ SSFLI 411_ LPFQR 416_ ITRLK 421_ LLVQN 426_ ILKRV 431_ EERSE 436_ RECTA 441_ LDAHK 446_ ELEMV 451_ VKACN 456_ EGVRK 461_ MSRTE 466_ QMISI 471_ QKKME 476_ FKIKS 481_ VPIIS 486_ HSRWL 491_ LKQGE 496_ LQQMS 501_ GPKTS 506_ RTLRT 511_ KKLFH 516_ EIYLF 521_ LFNDL 526_ LVICR 531_ QIPGD 536_ KYQVF 541_ DSAPR 546_ GLLRV 551_ EELED 556_ QGQTL 561_ ANVFI 566_ LRLLE 571_ NADDR 576_ EATYM 581_ LKASS 586_ QSEMK 591_ RWMTS 596_ LAPNR 601_ RTKFV 606_ SFTSR 611_ LLDCP 616_ QVQCV 621_ HPYVA 626_ QQPDE 631_ LTLEL 636_ ADILN 641_ ILDKT 646_ DDGWI 651_ FGERL 656_ HDQER 661_ GWFPS 666_ SMTEE 671_ ILNPK 676_ IRSQN 681_ LKECF 686_ RVHKM 691_ DDPQR 696_ SQNKD 701_RRKLG
1: Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity)