Male-specific lethal 3 homolog (Male-specific lethal-3 homolog 1) (Male-specific lethal-3 protein-like 1) (MSL3-like 1)
1_MSASE 6_ GMKFK 11_ FHSGE 16_ KVLCF 21_ EPDPT 26_ KARVL 31_ YDAKI 36_ VDVIV 41_ GKDEK 46_ GRKIP 51_ EYLIH 56_ FNGWN 61_ RSWDR 66_ WAAED 71_ HVLRD 76_ TDENR 81_ RLQRK 86_ LARKA 91_ VARLR 96_ STGRK 101_ KKRCR 106_ LPGVD 111_ SVLKG 116_ LPTEE 121_ KDEND 126_ ENSLS 131_ SSSDC 136_ SENKD 141_ EEISE 146_ ESDIE 151_ EKTEV 156_ KEEPE 161_ LQTRR 166_ EMEER 171_ TITIE 176_ IPEVL 181_ KKQLE 186_ DDCYY 191_ INRRK 196_ RLVKL 201_ PCQTN 206_ IITIL 211_ ESYVK 216_ HFAIN 221_ AAFSA 226_ NERPR 231_ HHHVM 236_ PHANM 241_ NVHYI 246_ PAEKN 251_ VDLCK 256_ EMVDG 261_ LRITF 266_ DYTLP 271_ LVLLY 276_ PYEQA 281_ QYKKV 286_ TSSKF 291_ FLPIK 296_ ESATS 301_ TNRSQ 306_ EELSP 311_ SPPLL 316_ NPSTP 321_ QSTES 326_ QPTTG 331_ EPATP 336_ KRRKA 341_ EPEAL 346_ QSLRR 351_ STRHS 356_ ANCDR 361_ LSESS 366_ ASPQP 371_ KRRQQ 376_ DTSAS 381_ MPKLF 386_ LHLEK 391_ KTPVH 396_ SRSSS 401_ PIPLT 406_ PSKEG 411_ SAVFA 416_ GFEGR 421_ RTNEI 426_ NEVLS 431_ WKLVP 436_ DNYPP 441_ GDQPP 446_ PPSYI 451_ YGAQH 456_ LLRLF 461_ VKLPE 466_ ILGKM 471_ SFSEK 476_ NLKAL 481_ LKHFD 486_ LFLRF 491_ LAEYH 496_ DDFFP 501_ ESAYV 506_ AACEA 511_ HYSTK 516_NPRAI
1: Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:16227571, PubMed:16543150, PubMed:20018852, PubMed:20657587, PubMed:20943666, PubMed:21217699, PubMed:30224647, PubMed:33837287). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). Acts as a histone reader that specifically recognizes and binds histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex (PubMed:20657587, PubMed:20943666). May play a role X inactivation in females (PubMed:21217699)