Protein mono-ADP-ribosyltransferase PARP16 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 15) (Poly [ADP-ribose] polymerase 16) (PARP-16)
1_MQPSG 6_ WAAAR 11_ EAAGR 16_ DMLAA 21_ DLRCS 26_ LFASA 31_ LQSYK 36_ RDSVL 41_ RPFPA 46_ SYARG 51_ DCKDF 56_ EALLA 61_ DASKL 66_ PNLKE 71_ LLQSS 76_ GDNHK 81_ RAWDL 86_ VSWIL 91_ SSKVL 96_ TIHSA 101_ GKAEF 106_ EKIQK 111_ LTGAP 116_ HTPVP 121_ APDFL 126_ FEIEY 131_ FDPAN 136_ AKFYE 141_ TKGER 146_ DLIYA 151_ FHGSR 156_ LENFH 161_ SIIHN 166_ GLHCH 171_ LNKTS 176_ LFGEG 181_ TYLTS 186_ DLSLA 191_ LIYSP 196_ HGHGW 201_ QHSLL 206_ GPILS 211_ CVAVC 216_ EVIDH 221_ PDVKC 226_ QTKKK 231_ DSKEI 236_ DRRRA 241_ RIKHS 246_ EGGDI 251_ PPKYF 256_ VVTNN 261_ QLLRV 266_ KYLLV 271_ YSQKP 276_ PKRAS 281_ SQLSW 286_ FSSHW 291_ FTVMI 296_ SLYLL 301_ LLLIV 306_ SVINS 311_ SAFQH 316_FWNRA
1: Intracellular mono-ADP-ribosyltransferase that plays a role in different processes, such as protein translation and unfolded protein response (UPR), through the mono-ADP-ribosylation of proteins involved in those processes (PubMed:22701565, PubMed:23103912, PubMed:25043379, PubMed:34314702). Acts as an inhibitor of protein translation by catalyzing mono-ADP-ribosylation of ribosomal subunits, such as RPL14 and RPS6, thereby inhibiting polysome assembly and mRNA loading (PubMed:34314702). Mono-ADP-ribosylation of ribosomal subunits is promoted by NMNAT2 (PubMed:34314702). Involved in the unfolded protein response (UPR) by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors (PubMed:23103912). May also mediate mono-ADP-ribosylation of karyopherin KPNB1 a nuclear import factor (PubMed:22701565). May not modify proteins on arginine or cysteine residues compared to other mono-ADP-ribosyltransferases (PubMed:22701565)