Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial (KAT/AadAT) (2-aminoadipate aminotransferase) (2-aminoadipate transaminase) (EC 2.6.1.39) (Alpha-aminoadipate aminotransferase) (AadAT) (Glycine transaminase AADAT) (EC 2.6.1.4) (Kynurenine aminotransferase II) (Kynurenine--glyoxylate transaminase AADAT) (EC 2.6.1.63) (Kynurenine--oxoglutarate aminotransferase II) (Kynurenine--oxoglutarate transaminase 2) (EC 2.6.1.7) (Kynurenine--oxoglutarate transaminase II) (Methionine--glyoxylate transaminase AADAT) (EC 2.6.1.73)
1_MNYAR 6_ FITAA 11_ SAARN 16_ PSPIR 21_ TMTDI 26_ LSRGP 31_ KSMIS 36_ LAGGL 41_ PNPNM 46_ FPFKT 51_ AVITV 56_ ENGKT 61_ IQFGE 66_ EMMKR 71_ ALQYS 76_ PSAGI 81_ PELLS 86_ WLKQL 91_ QIKLH 96_ NPPTI 101_ HYPPS 106_ QGQMD 111_ LCVTS 116_ GSQQG 121_ LCKVF 126_ EMIIN 131_ PGDNV 136_ LLDEP 141_ AYSGT 146_ LQSLH 151_ PLGCN 156_ IINVA 161_ SDESG 166_ IVPDS 171_ LRDIL 176_ SRWKP 181_ EDAKN 186_ PQKNT 191_ PKFLY 196_ TVPNG 201_ NNPTG 206_ NSLTS 211_ ERKKE 216_ IYELA 221_ RKYDF 226_ LIIED 231_ DPYYF 236_ LQFNK 241_ FRVPT 246_ FLSMD 251_ VDGRV 256_ IRADS 261_ FSKII 266_ SSGLR 271_ IGFLT 276_ GPKPL 281_ IERVI 286_ LHIQV 291_ STLHP 296_ STFNQ 301_ LMISQ 306_ LLHEW 311_ GEEGF 316_ MAHVD 321_ RVIDF 326_ YSNQK 331_ DAILA 336_ AADKW 341_ LTGLA 346_ EWHVP 351_ AAGMF 356_ LWIKV 361_ KGIND 366_ VKELI 371_ EEKAV 376_ KMGVL 381_ MLPGN 386_ AFYVD 391_ SSAPS 396_ PYLRA 401_ SFSSA 406_ SPEQM 411_ DVAFQ 416_VLAQL
1: Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro)