Gene name: KCTD17

Uniprot entry:

Q8N5Z5

Protein names:

BTB/POZ domain-containing protein KCTD17

Protein sequence:

1_MQTPR 6_ PAMRM 11_ EAGEA 16_ APPAG 21_ AGGRA 26_ AGGWG 31_ KWVRL 36_ NVGGT 41_ VFLTT 46_ RQTLC 51_ REQKS 56_ FLSRL 61_ CQGEE 66_ LQSDR 71_ DETGA 76_ YLIDR 81_ DPTYF 86_ GPILN 91_ FLRHG 96_ KLVLD 101_ KDMAE 106_ EGVLE 111_ EAEFY 116_ NIGPL 121_ IRIIK 126_ DRMEE 131_ KDYTV 136_ TQVPP 141_ KHVYR 146_ VLQCQ 151_ EEELT 156_ QMVST 161_ MSDGW 166_ RFEQL 171_ VNIGS 176_ SYNYG 181_ SEDQA 186_ EFLCV 191_ VSKEL 196_ HSTPN 201_ GLSSE 206_ SSRKT 211_ KSTEE 216_ QLEEQ 221_ QQQEE 226_ EVEEV 231_ EVEQV 236_ QVEAD 241_ AQEKA 246_ QSSQD 251_ PANLF 256_ SLPPL 261_ PPPPL 266_ PAGGS 271_ RPHPL 276_ RPEAE 281_ LAVRA 286_ SPRPL 291_ ARPQS 296_ CHPCC 301_ YKPEA 306_ PGCEA 311_ PDHLQ 316_GLGVP

Protein annotations

Protein functions:

1: Substrate-adapter for CUL3-RING ubiquitin ligase complexes which mediates the ubiquitination and subsequent proteasomal degradation of TCHP, a protein involved in ciliogenesis down-regulation. Thereby, positively regulates ciliogenesis, playing a crucial role in the initial steps of axoneme extension (PubMed:25270598). May also play a role in endoplasmic reticulum calcium ion homeostasis (PubMed:25983243)