Cleavage and polyadenylation specificity factor subunit 7 (Cleavage and polyadenylation specificity factor 59 kDa subunit) (CPSF 59 kDa subunit) (Cleavage factor Im complex 59 kDa subunit) (CFIm59) (Pre-mRNA cleavage factor Im 59 kDa subunit)
1_MSEGV 6_ DLIDI 11_ YADEE 16_ FNQDP 21_ EFNNT 26_ DQIDL 31_ YDDVL 36_ TATSQ 41_ PSDDR 46_ SSSTE 51_ PPPPV 56_ RQEPS 61_ PKPNN 66_ KTPAI 71_ LYTYS 76_ GLRNR 81_ RAAVY 86_ VGSFS 91_ WWTTD 96_ QQLIQ 101_ VIRSI 106_ GVYDV 111_ VELKF 116_ AENRA 121_ NGQSK 126_ GYAEV 131_ VVASE 136_ NSVHK 141_ LLELL 146_ PGKVL 151_ NGEKV 156_ DVRPA 161_ TRQNL 166_ SQFEA 171_ QARKR 176_ ECVRV 181_ PRGGI 186_ PPRAH 191_ SRDSS 196_ DSADG 201_ RATPS 206_ ENLVP 211_ SSARV 216_ DKPPS 221_ VLPYF 226_ NRPPS 231_ ALPLM 236_ GLPPP 241_ PIPPP 246_ PPLSS 251_ SFGVP 256_ PPPPG 261_ IHYQH 266_ LMPPP 271_ PRLPP 276_ HLAVP 281_ PPGAI 286_ PPALH 291_ LNPAF 296_ FPPPN 301_ ATVGP 306_ PPDTY 311_ MKASA 316_ PYNHH 321_ GSRDS 326_ GPPPS 331_ TVSEA 336_ EFEDI 341_ MKRNR 346_ AISSS 351_ AISKA 356_ VSGAS 361_ AGDYS 366_ DAIET 371_ LLTAI 376_ AVIKQ 381_ SRVAN 386_ DERCR 391_ VLISS 396_ LKDCL 401_ HGIEA 406_ KSYSV 411_ GASGS 416_ SSRKR 421_ HRSRE 426_ RSPSR 431_ SRESS 436_ RRHRD 441_ LLHNE 446_ DRHDD 451_ YFQER 456_ NREHE 461_ RHRDR 466_ERDRH
1: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:17024186, PubMed:29276085, PubMed:8626397). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:17024186, PubMed:8626397). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF7 activates directly the mRNA 3'-processing machinery (PubMed:29276085). Binds to pA signals in RNA substrates (PubMed:17024186, PubMed:8626397)