Homeobox protein ESX1 (Extraembryonic, spermatogenesis, homeobox 1) [Cleaved into: Homeobox protein ESX1-N; Homeobox protein ESX1-C]
1_MESLR 6_ GYTHS 11_ DIGYR 16_ SLAVG 21_ EDIEE 26_ VNDEK 31_ LTVTS 36_ LMARG 41_ GEDEE 46_ NTRSK 51_ PEYGT 56_ EAENN 61_ VGTEG 66_ SVPSD 71_ DQDRE 76_ GGGGH 81_ EPEQQ 86_ QEEPP 91_ LTKPE 96_ QQQEE 101_ PPLLE 106_ LKQEQ 111_ EEPPQ 116_ TTVEG 121_ PQPAE 126_ GPQTA 131_ EGPQP 136_ PERKR 141_ RRRTA 146_ FTQFQ 151_ LQELE 156_ NFFDE 161_ SQYPD 166_ VVARE 171_ RLAAR 176_ LNLTE 181_ DRVQV 186_ WFQNR 191_ RAKWK 196_ RNQRV 201_ LMLRN 206_ TATAD 211_ LAHPL 216_ DMFLG 221_ GAYYA 226_ APALD 231_ PALCV 236_ HLVPQ 241_ LPRPP 246_ VLPVP 251_ PMPPR 256_ PPMVP 261_ MPPRP 266_ PIAPM 271_ PPMAP 276_ VPPGS 281_ RMAPV 286_ PPGPR 291_ MAPVP 296_ PWPPM 301_ APVPP 306_ WPPMA 311_ PVPTG 316_ PPMAP 321_ VPPGP 326_ PMARV 331_ PPGPP 336_ MARVP 341_ PGPPM 346_ APLPP 351_ GPPMA 356_ PLPPG 361_ PPMAP 366_ LPPGP 371_ PMAPL 376_ PPRSH 381_ VPHTG 386_ LAPVH 391_ ITWAP 396_ VINSY 401_YACPF
1: May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5'-TAATGTTATTA-3' which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover