Sodium-coupled monocarboxylate transporter 1 (Apical iodide transporter) (Electrogenic sodium monocarboxylate cotransporter) (Sodium iodide-related cotransporter) (Solute carrier family 5 member 8)
1_MDTPR 6_ GIGTF 11_ VVWDY 16_ VVFAG 21_ MLVIS 26_ AAIGI 31_ YYAFA 36_ GGGQQ 41_ TSKDF 46_ LMGGR 51_ RMTAV 56_ PVALS 61_ LTASF 66_ MSAVT 71_ VLGTP 76_ SEVYR 81_ FGAIF 86_ SIFAF 91_ TYFFV 96_ VVISA 101_ EVFLP 106_ VFYKL 111_ GITST 116_ YEYLE 121_ LRFNK 126_ CVRLC 131_ GTVLF 136_ IVQTI 141_ LYTGI 146_ VIYAP 151_ ALALN 156_ QVTGF 161_ DLWGA 166_ VVATG 171_ VVCTF 176_ YCTLG 181_ GLKAV 186_ IWTDV 191_ FQVGI 196_ MVAGF 201_ ASVII 206_ QAVVM 211_ QGGIS 216_ TILND 221_ AYDGG 226_ RLNFW 231_ NFNPN 236_ PLQRH 241_ TFWTI 246_ IIGGT 251_ FTWTS 256_ IYGVN 261_ QSQVQ 266_ RYISC 271_ KSRFQ 276_ AKLSL 281_ YINLV 286_ GLWAI 291_ LTCSV 296_ FCGLA 301_ LYSRY 306_ HDCDP 311_ WTAKK 316_ VSAPD 321_ QLMPY 326_ LVLDI 331_ LQDYP 336_ GLPGL 341_ FVACA 346_ YSGTL 351_ STVSS 356_ SINAL 361_ AAVTV 366_ EDLIK 371_ PYFRS 376_ LSERS 381_ LSWIS 386_ QGMSV 391_ VYGAL 396_ CIGMA 401_ ALASL 406_ MGALL 411_ QAALS 416_ VFGMV 421_ GGPLM 426_ GLFAL 431_ GILVP 436_ FANSI 441_ GALVG 446_ LMAGF 451_ AISLW 456_ VGIGA 461_ QIYPP 466_ LPERT 471_ LPLHL 476_ DIQGC 481_ NSTYN 486_ ETNLM 491_ TTTEM 496_ PFTTS 501_ VFQIY 506_ NVQRT 511_ PLMDN 516_ WYSLS 521_ YLYFS 526_ TVGTL 531_ VTLLV 536_ GILVS 541_ LSTGG 546_ RKQNL 551_ DPRYI 556_ LTKED 561_ FLSNF 566_ DIFKK 571_ KKHVL 576_ SYKSH 581_ PVEDG 586_ GTDNP 591_ AFNHI 596_ ELNSD 601_QSGKS
1: Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1 (PubMed:14966140, PubMed:15090606, PubMed:16729224, PubMed:16805814, PubMed:17178845, PubMed:17245649, PubMed:17526579, PubMed:20211600, PubMed:30604288). Catalyzes passive carrier mediated diffusion of iodide (PubMed:12107270). Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane (PubMed:12107270). May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract (PubMed:17245649). Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines (PubMed:12829793, PubMed:15867356, PubMed:18037591). May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons (PubMed:16805814). Mediates sodium-coupled electrogenic transport of pyroglutamate (5-oxo-L-proline) (PubMed:20211600). Can mediate the transport of chloride, bromide, iodide and nitrate ions when the external concentration of sodium ions is reduced (PubMed:19864324)