Solute carrier family 15 member 4 (Peptide transporter 4) (Peptide/histidine transporter 1) (hPHT1)
1_MEGSG 6_ GGAGE 11_ RAPLL 16_ GARRA 21_ AAAAA 26_ AAGAF 31_ AGRRA 36_ ACGAV 41_ LLTEL 46_ LERAA 51_ FYGIT 56_ SNLVL 61_ FLNGA 66_ PFCWE 71_ GAQAS 76_ EALLL 81_ FMGLT 86_ YLGSP 91_ FGGWL 96_ ADARL 101_ GRARA 106_ ILLSL 111_ ALYLL 116_ GMLAF 121_ PLLAA 126_ PATRA 131_ ALCGS 136_ ARLLN 141_ CTAPG 146_ PDAAA 151_ RCCSP 156_ ATFAG 161_ LVLVG 166_ LGVAT 171_ VKANI 176_ TPFGA 181_ DQVKD 186_ RGPEA 191_ TRRFF 196_ NWFYW 201_ SINLG 206_ AILSL 211_ GGIAY 216_ IQQNV 221_ SFVTG 226_ YAIPT 231_ VCVGL 236_ AFVVF 241_ LCGQS 246_ VFITK 251_ PPDGS 256_ AFTDM 261_ FKILT 266_ YSCCS 271_ QKRSG 276_ ERQSN 281_ GEGIG 286_ VFQQS 291_ SKQSL 296_ FDSCK 301_ MSHGG 306_ PFTEE 311_ KVEDV 316_ KALVK 321_ IVPVF 326_ LALIP 331_ YWTVY 336_ FQMQT 341_ TYVLQ 346_ SLHLR 351_ IPEIS 356_ NITTT 361_ PHTLP 366_ AAWLT 371_ MFDAV 376_ LILLL 381_ IPLKD 386_ KLVDP 391_ ILRRH 396_ GLLPS 401_ SLKRI 406_ AVGMF 411_ FVMCS 416_ AFAAG 421_ ILESK 426_ RLNLV 431_ KEKTI 436_ NQTIG 441_ NVVYH 446_ AADLS 451_ LWWQV 456_ PQYLL 461_ IGISE 466_ IFASI 471_ AGLEF 476_ AYSAA 481_ PKSMQ 486_ SAIMG 491_ LFFFF 496_ SGVGS 501_ FVGSG 506_ LLALV 511_ SIKAI 516_ GWMSS 521_ HTDFG 526_ NINGC 531_ YLNYY 536_ FFLLA 541_ AIQGA 546_ TLLLF 551_ LIISV 556_ KYDHH 561_ RDHQR 566_ SRANG 571_VPTSR
1: Proton-coupled amino-acid transporter that mediates the transmembrane transport of L-histidine and some di- and tripeptides from inside the lysosome to the cytosol, and plays a key role in innate immune response (PubMed:16289537, PubMed:25238095, PubMed:29224352). Able to transport a variety of di- and tripeptides, including carnosine and some peptidoglycans (PubMed:29224352, PubMed:31073693). Transporter activity is pH-dependent and maximized in the acidic lysosomal environment (By similarity). Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand, and L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate (tri-DAP), the NOD1 ligand (PubMed:25238095, PubMed:29224352). Required for TLR7, TLR8 and TLR9-mediated type I interferon (IFN-I) productions in plasmacytoid dendritic cells (pDCs) (PubMed:25238095). Independently of its transporter activity, also promotes the recruitment of innate immune adapter TASL to endolysosome downstream of TLR7, TLR8 and TLR9: TASL recruitment leads to the specific recruitment and activation of IRF5 (PubMed:32433612). Required for isotype class switch recombination to IgG2c isotype in response to TLR9 stimulation (By similarity). Required for mast cell secretory-granule homeostasis by limiting mast cell functions and inflammatory responses (By similarity)