Myc target protein 1 (Myc target in myeloid cells protein 1)
1_MRTQV 6_ YEGLC 11_ KNYFS 16_ LAVLQ 21_ RDRIK 26_ LLFFD 31_ ILVFL 36_ SVFLL 41_ FLLFL 46_ VDIMA 51_ NNTTS 56_ LGSPW 61_ PENFW 66_ EDLIM 71_ SFTVS 76_ MAIGL 81_ VLGGF 86_ IWAVF 91_ ICLSR 96_ RRRAS 101_ APISQ 106_ WSSSR 111_ RSRSS 116_ YTHGL 121_ NRTGF 126_ YRHSG 131_ CERRS 136_ NLSLA 141_ SLTFQ 146_ RQASL 151_ EQANS 156_ FPRKS 161_ SFRAS 166_ TFHPF 171_ LQCPP 176_ LPVET 181_ ESQLV 186_ TLPSS 191_ NISPT 196_ ISTSH 201_ SLSRP 206_ DYWSS 211_ NSLRV 216_ GLSTP 221_ PPPAY 226_ESIIK
1: May regulate certain MYC target genes, MYC seems to be a direct upstream transcriptional activator. Does not seem to significantly affect growth cell capacity. Overexpression seems to mediate many of the known phenotypic features associated with MYC, including promotion of apoptosis, alteration of morphology, enhancement of anchorage-independent growth, tumorigenic conversion, promotion of genomic instability, and inhibition of hematopoietic differentiation (By similarity)