Leukocyte immunoglobulin-like receptor subfamily A member 3 (CD85 antigen-like family member E) (Immunoglobulin-like transcript 6) (ILT-6) (Leukocyte immunoglobulin-like receptor 4) (LIR-4) (Monocyte inhibitory receptor HM43/HM31) (CD antigen CD85e)
1_MTPIL 6_ TVLIC 11_ LGLSL 16_ DPRTH 21_ VQAGP 26_ LPKPT 31_ LWAEP 36_ GSVIT 41_ QGSPV 46_ TLRCQ 51_ GSLET 56_ QEYHL 61_ YREKK 66_ TALWI 71_ TRIPQ 76_ ELVKK 81_ GQFPI 86_ LSITW 91_ EHAGR 96_ YCCIY 101_ GSHTA 106_ GLSES 111_ SDPLE 116_ LVVTG 121_ AYSKP 126_ TLSAL 131_ PSPVV 136_ TSGGN 141_ VTIQC 146_ DSQVA 151_ FDGFI 156_ LCKEG 161_ EDEHP 166_ QCLNS 171_ HSHAR 176_ GSSRA 181_ IFSVG 186_ PVSPS 191_ RRWSY 196_ RCYGY 201_ DSRAP 206_ YVWSL 211_ PSDLL 216_ GLLVP 221_ GVSKK 226_ PSLSV 231_ QPGPV 236_ VAPGE 241_ KLTFQ 246_ CGSDA 251_ GYDRF 256_ VLYKE 261_ WGRDF 266_ LQRPG 271_ RQPQA 276_ GLSQA 281_ NFTLG 286_ PVSRS 291_ YGGQY 296_ TCSGA 301_ YNLSS 306_ EWSAP 311_ SDPLD 316_ ILITG 321_ QIRAR 326_ PFLSV 331_ RPGPT 336_ VASGE 341_ NVTLL 346_ CQSQG 351_ GMHTF 356_ LLTKE 361_ GAADS 366_ PLRLK 371_ SKRQS 376_ HKYQA 381_ EFPMS 386_ PVTSA 391_ HAGTY 396_ RCYGS 401_ LSSNP 406_ YLLTH 411_ PSDPL 416_ ELVVS 421_ GAAET 426_ LSPPQ 431_NKSDS
1: Acts as a soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes