E3 ubiquitin-protein ligase RNF182 (EC 2.3.2.27) (RING finger protein 182) (RING-type E3 ubiquitin transferase RNF182)
1_MASQP 6_ PEDTA 11_ ESQAS 16_ DELEC 21_ KICYN 26_ RYNLK 31_ QRKPK 36_ VLECC 41_ HRVCA 46_ KCLYK 51_ IIDFG 56_ DSPQG 61_ VIVCP 66_ FCRFE 71_ TCLPD 76_ DEVSS 81_ LPDDN 86_ NILVN 91_ LTCGG 96_ KGKKC 101_ LPENP 106_ TELLL 111_ TPKRL 116_ ASLVS 121_ PSHTS 126_ SNCLV 131_ ITIME 136_ VQRES 141_ SPSLS 146_ STPVV 151_ EFYRP 156_ ASFDS 161_ VTTVS 166_ HNWTV 171_ WNCTS 176_ LLFQT 181_ SIRVL 186_ VWLLG 191_ LLYFS 196_ SLPLG 201_ IYLLV 206_ SKKVT 211_ LGVVF 216_ VSLVP 221_ SSLVI 226_ LMVYG 231_ FCQCV 236_ CHEFL 241_DCMAP
1: E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway (PubMed:18298843). Also plays a role in the inhibition of TLR-triggered innate immune response by mediating 'Lys'-48-linked ubiquitination and subsequent degradation of NF-kappa-B component RELA (PubMed:31432514)