Germinal center-associated signaling and motility protein (Germinal center B-cell-expressed transcript 2 protein) (Germinal center-associated lymphoma protein) (hGAL)
1_MGNSL 6_ LRENR 11_ RQQNT 16_ QEMPW 21_ NVRMQ 26_ SPKQR 31_ TSRCW 36_ DHHIA 41_ EGCFC 46_ LPWKK 51_ ILIFE 56_ KRQDS 61_ QNENE 66_ RMSST 71_ PIQDN 76_ VDQTY 81_ SEELC 86_ YTLIN 91_ HRVLC 96_ TRPSG 101_ NSAEE 106_ YYENV 111_ PCKAE 116_ RPRES 121_ LGGTE 126_ TEYSL 131_ LHMPS 136_ TDPRH 141_ ARSPE 146_ DEYEL 151_ LMPHR 156_ ISSHF 161_ LQQPR 166_ PLMAP 171_SETQF
1: Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation